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12 Cards in this Set
- Front
- Back
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where is insulin produced?
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Beta cells of the pancreas Islets of Langerhans
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What actions does insulin have?
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promotes glucose uptake
promotes protein synthesis promotes glycogen synthesis promotes fat synthesis inhibits liberation of FFAs inhibits gluconeogenesis |
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How does insulin exert it's effects?
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binds insulin receptors in sensitive tissues, receptor is a tyrosine kinase that phosphorylates and dephosphorylates things
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What therapuetic uses does insulin have?
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treatment of Diabetes Mellitus
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What are the symptoms of diabetes mellitus?
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PU/PD, weight loss, lethargy, glucosuria, hyperglycemia
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What is the goal of treatment with insulin?
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decrease blood glucose to near normal
-don't want to overdo it and get hypoglycemia! |
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What are the fast acting insulin preparations?
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regular insulin (human source)
Lispro and Aspart (synthetic) |
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What are the intermediate to long acting insulin preparations?
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NPH (human source)
Protamine zinc pork insulin Glargine and Detemir (synthetic) |
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What are fast acting insulin preps used for?
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emergency, complicated diabetes (ketoacidosis, anorexia etc)
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How should insulin be stored?
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Can be stored at room temperature, but should be kept out of sunlight etc so can be best to store in refrigerator
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What is the purpose of sulfonylureas in hyperglycemia?
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inhibit ATP dependent K channels, depolarizing beta cells to release insulin
*only works if cells are capable of secreting insulin *not very useful in dogs, trigger amyloid deposition in cats! |
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What are the ADEs of insulin?
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acute hypoglycemia
trembling, confusion, coma MAY cause Ab formation |
