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11 Cards in this Set
- Front
- Back
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NREM
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lowered physiological fxn
restore various physiological and ummunological fxns |
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REM
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increased neuronal activity
similar or greater psysiological fsx as wakefulness abstract dreaming important for memory and learning |
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tx of insomnia
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BZD
or non-bzd hypnotic agents: antidepr, antihist, ethanol, chloral hydrate, warm milk and cookies |
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BZD
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increases GABA tansmission
increase total sleep time decreases REM and deep sleep |
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Sedating Antidepressants
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tricyclic, trazodone, and mirtazapine
blocks reuptake of serotonin and NE long t 1/2 results in next day sedation may take 4-6 weeks high potential for drug interaction |
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What are the SE of sedating antidepressants?
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anticholinergic
orthostatic hypotension hypothermia seizures cardiotoxicity |
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Antihistimines
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OTC medication
Sleep eze, unisom, sominex, and nytol anticholingeric side effects residual drowsiness |
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Chloral Hydrate
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rarely used
converste to trichloroethanol hangover ADE- GI, drug interactions transfers to breast milk |
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melatonin
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hormone secreted by pineal gland and synthesized from trytophan
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ramelteon
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highly selective MT1 and MT2 receptors
longer t1/2 than melatonin no hangover effects ADE- somnolence, dizziness and fatigue |
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Valerian
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inhibits GABA reuptake
ADE- hA, excitability, and cardiac disturbances associated with uterine contractions cause of hepatitis and liver damage |
