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35 Cards in this Set
- Front
- Back
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Cellular receptors for microbial antigens on innate immune cells
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Pathogen recognition receptors
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LPS, peptidoglycan, lipoteichoic acid, viral RNA, fungal mannans
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Pathogen associated molecular patterns
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General characteristics of innate immunity
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No induction period, specificity or memory
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Extensive physical barrier to infection
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Epithelial lining of portals of entry
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Most active phagocytic cell and most abundant circulating WBC
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Neutrophil
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Neutrophils, macrophages, dendritic cells, B cells
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Phagocytic cells
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Lysozyme, reactive oxygen intermediates, nitric oxide
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Microbicidal molecules of phagocytes
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Enzyme responsible for production of reactive oxygen species
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Phagocyte oxidase
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Pro-inflammatory cytokines that target endothelium, among others
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TNF, IL-1
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Adhesion molecules expressed on endothelium that mediate rolling of leukocytes
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E and P Selectins
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Adhesion molecules expressed on leukocytes that mediate tethering of leukocytes
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Integrins
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Lymphocytes of innate immunity that provide early defense against viral infections
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NK cells
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Major source of interferon-IFN) in innate immune system
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NK cells
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Structural domains found on inhibitory receptors of NK cells
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ITIMs
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Structural domains found on activating receptors of NK cells
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ITAMs
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Intraepithelial lymphocytes that are early sentinels of bacterial infections
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gamma, delta T cells
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Activator of classical pathway of complement
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Antibody binding to C1q
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Activator of alternative pathway of complement
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Binding of C3b to microbial surfaces
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Activator of lectin pathway of complement
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Terminal mannose residues of microbial glycoproteins
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Major opsonin generated by complement activation
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C3b
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Pro-inflammatory molecules generated by complement activation
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C3a and C5a
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Polymeric protein complex that lyses microbes
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Membrane Attack Complex (MAC); C6-C9
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Cytokines that activate endothelium
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TNF and IL-1
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Class of cytokines that increase integrin affinity and are chemotacic
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Chemokines
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Cytokine that induces interferon- production by NK cells and T cells
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IL-12
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Cytokine that activates macrophages
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IFN(gamma)
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Anti-viral cytokines
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IFN(alpha)/(beta) (Type I IFNs)
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Cytokine that down-regulates immune responses
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IL-10
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Pro-inflammatory cytokines
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TNF, IL-1, IL-6
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Inducers of the acute phase response
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IL-6, TNF, IL-1
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Induces proliferation of plasma cells
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IL-6
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C-reactive protein, mannose-binding lectin and others
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Acute phase proteins
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Signals generated by innate immune response to stimulate lymphocytes
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B7, C3d and IL-12
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Substances given with vaccines that stimulate immune responses
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Adjuvants
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Neutrophils, macrophages, lymphocytes, basophils, eosinophils
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Cells quantified on a CBC
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