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3 Cards in this Set
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- Back
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Sulfonamides
Sulfamethoxazole-Trimethoprim Silver Sulfadiazine, topical Sulfasalazine, PO Fansidar (sulfadioxine + pyrimethamine) |
Uses: Trimethoprim + sulfamethoxazole = Pneumocystis jiroveci
Pyrimethamine + sulfadiazine = toxoplamasic encephalitis Silver sulfadiazine = burns Sulfasalazine = ulcerative colitis Fansidar = chloroquine-resistant P. falciparum malaria MOA: inhibit PABA into dihydropteroic acid, blocking folate metabolism, inhibits DHFR. Pharm: PO/topical, +CNS, +placenta, acetylated liver, excreted kidney Effects: Kernicterus in babies, metabolic acidosis b/c of mafenide metabolite that inhibits CA, crystalluria, acute hemolytic anemia c/ decreased G6PD dehydrogenase, skin rashes, Steven-Johnson |
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Fluoroquinolones
Ciprofloxacin Moxifloxacin Levofloxacin Gemifloxacin |
Uses: UTI, Pseudomonas aeruginosa, Salmonella, Shigella, E. coli (Traveler's diarrhea), atypical pneumonia, MAC, Enterobacter
MOA: inhibit topo II & IV Pharm: PO, +CNS, excreted kidney Effects: arthropathy in cartilage, prolong QT intervals, N/V, HA |
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Metronidazole
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Uses: Luminal amebiasis, Giardiasis, Trichomoniasis, Pseudomembranous Colitis
MOA: reduced by nitroreductase enzymes to target DNA for cytotoxicity Pharm: PO, +CSF, metabolized liver Effects: Disulfiram-like reaction, metallic taste, neurotoxicity |
