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10 Cards in this Set
- Front
- Back
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What is the unitary hypothesis of general anesthesia?
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All anesthetics exert their action by the same mechanism
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What is Pam's wrong unitary hypothesis?
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the critical volume hypothesis: Anesthesia is produced by volume of anesthesia molecules disolved at site
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What is furguson's rule?
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Anesthetic potency correlates with vapor pressure
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Describe potency?
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A thermodynamic property (solubility), not related to site of action
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Are anesthetics often homologous chemicals?
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Yes
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How does anesthetic potency relate to number of carbons in the chain?
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Potency increases logarythmically with carbons until it suddenly drops off
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Do general anesthetics exhibit stereoselectivity?
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No (e.g. halothane, but not iso)
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What is the effect of increased pressure on anesthesia?
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Antagonism of anesthetic effects
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Which is the righting reflex?
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The ability of an animal to right itself after it has been turned over
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What is the lipid solubility hypothesis?
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Old therory, predicts GA occurs when anesthetic concentration reaches 25-50 mmol/l in the lipid bilayer of the cell membrane
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