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36 Cards in this Set
- Front
- Back
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Histamine
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vasodilates and increases mucus
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Prostaglandins
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vasodilate and increase permeability
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Leukotriens
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increase mucus and bronchoconstrict
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Chemokines
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attract cells to site
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Platelet activating factor (PAF)
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involved with chemotaxis and activating PMN's
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C3a and C4a
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increase vasodilation, increase permeability, Anaphylatoxin, and phagocyte recruitment
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C5a
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increase vasodilation, increase permeability, anaphylatoxin
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Anaphylatoxin
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are fragments (C3a, C4a and C5a) that are produced as part of the activation of the complement system
Produce inflammatory response |
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Epo
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stimulates production RBC's
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TNF
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Triggers Apoptosis, increases CAMs, increase fever, increase cytokines
Proinflammatory |
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IL-1
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Proinflammatory, activates endothelium, induces fever
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IL-2
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T, B, and NK cell Activation/proliferation
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IL-3
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development of hematopoietic cells
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IL-4
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made by TH2
signals B cell proliferation signals isotype switch to IgE |
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IL-5
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made by TH2
Eosinophil activation and recruitment induces isotype switch to IgA |
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IL-6
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induces acute phase proteins
promotes plasma cell proliferation |
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IL-10
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made by macrophages and TH2
inhibits macrophage & dendritic cell fxn |
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IL-12
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made by macrophages and dendritic cells
stimulates Interferon gamma Stimulates production of TH1 cells |
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IL-17
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pro-inflammatory
recruits neutrophils |
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Interferon alpha and beta
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antiviral
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Interferon gamma type II
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Macrophage and NK activation
Production of TH1 increases MHC expression |
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G-CSF
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stimulates granulocytes and stem cells
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M-CSF
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stimulates monos and macros
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GM-CSF
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stimulates granulocytes and monocytes
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Transforming growth factor Beta
(TGF-Beta) |
inhibits T & B cell proliferation
Promotes Ab switch to isotype IgA |
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CD3
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T-cells
Signal trasduction by the TCR |
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CD4
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Regulator T cells
Bind class II MHC |
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CD8
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Killer T-Cells
Bind class I MHC |
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CD19 CD20 CD21
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B- Cell markers
higher CD number = more mature |
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CD28
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Binds B7-1 (CD80) and B7-2 (CD86) as costimulator
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CD40
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Binds CD40L (CD154) on T cells to provide T-cell help
if there is a deficiency of CD40 = hyper IgM |
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CD80
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Costimulator for T-cell activation
binds CD28 & turns T-cell on |
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CD86
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Costimulator for T-cell activation
Binds CD28 and turns T-cell on |
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CD95
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Binds Fas ligand to activate apoptosis
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CD152
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Inhibitor signal for T-cells
Binds CD80 and CD86 on APC |
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CD154
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The CD40 Ligand
Activates B-Cells |
