Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
Cardinal signs of inflammation?
|
1. Rubor (redness)
2. Calor (heat) 3. Tumor (swelling) 4. Dolor (pain) 5. Functio laesa (loss of function) |
|
|
Chain of events with inflammation?
|
Congestion = vessels dilate, slowing of vascular flow; red flush.
Change in vascular permeability- - fluid - exudate Leukocyte (WBC) exudation |
|
|
Mediators of Inflammation?
|
1. Histamines (inital event)
2. Next, - Kinin system (response to pain) - Complement system (protein) - Coagulation system (fibrinogen --> fibrin) 3. Then, - Prostoglandins (PG) - Leukotrienes (LT) |
|
|
Chemokines...
|
- Small proteins (50 known) that direct the movement of circulating leukocytes to site of inflammation.
- Affect cells by activating surface receptors. Binding activates signalling cascade. |
|
|
Dependent factors of inflammation?
|
1. nutrition
2. age 3. blood supply 4. presence of foreign body 5. presence of medication |
|
|
ACUTE inflammation
|
Polymorphonuclear leukocytes. AKA:
- PMNs - POLYs - Phagocytes - Neutrophils TWO PARTS: 1. inflammation 2. repair A. Regeneration (same tissue) B. Replacement (fibrous/scar tissue) |
|
|
CHRONIC inflammation
|
1. No POLYs.
2. Presence of "round cells:" - lymphocytes - plasma cells - macrophages 3. Fibrosis. |
|
|
Types of cells and their regenerative capacity?
|
PROFOUND CAPACITY = labile cells.
(skin, epithelium of GI, bone marrow, sex cells) INTERMEDIATE CAPACITY = Stable cells (liver, kidney) "NO" CAPACITY = Permanent cells (cardiac muscle, CNS) |
|
|
How to test for acute inflammation?
|
1. Erythrocyte Sedimentation Rate (AKA ESR, Sed rate). Measures settling of RBC in blood sample. FASTER than normal with inflammation.
2. C-Reactive Protein. (CRP) Some question if CRP measures or causes inflammation. |
