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16 Cards in this Set
- Front
- Back
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May be cytokine responsible for activating T-cells in arthritis; produced mainly be macrophages
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IL-15
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Increases B cell proliferation and immunoglobulin production and, therefore, may be involved in producing the rheumatoid factor (RF); enhances the formation of acute phase reactants from the liver and is involved in bone resorption
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IL-6
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classified as a chemokine due to its powerful chemotactic properties for neutrophils and up-regulation of adhesion molecules. Secreted from macrophages and endothelial cells with specificity on neutrophils and less on monocytes and eosinophils. IL-1 and TNF are potent inducers of IL-8!!!!! Other examples of chemokines are MCP-1 (monocyte chemoattractant) and RANTES (regulated and normal T cell expressed and secreted) released from lymphocytes and attract monocytes, lymphocytes, eosinophils and basophils, BUT NOT neutrophils. Involved in different types of inflammation.
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IL-8
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Anti-inflammatory Cytokines
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IL-4, IL-10, IL-13
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Also called lymphotoxin; released from T-lymphocytes and NK-cells
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TNF-beta
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Preformed cellular-derived mediators
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Histamine, Serotonin, Proteases (lysosomal enzymes)
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Plasma derived mediators
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complement, kinin, clotting (systems)
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Confined to endothelial cells- bind to receptors on white cells
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E-selectin
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B2 receptor for bradykinin function to:
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1. Smooth muscle contraction
2. Inc. Vas perm 3. Vasodilation 4. Stim. sensory nerve endings 5. Rel. Substance P 6. Degranulated Mast cells |
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B1 receptor for bradykinin function to:
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1. Smooth muscle contraction
2. Bone resorption 3. Rel Pgs 4. Rel Interleukins & TNF |
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Fibrinopetides of the clotting system are converted from fibrinogen by thrombin to:
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increase vascular perm, & are chemotatic
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Thrombin
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Increases formation of adhesion molecules
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Factor Xa
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increases vascular permeability
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Produced from MACROPHAGES (also T-cells, NK cells, mast cells) promotes 1) Cartilage degradation & 2) stim. bone resoprtion
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TNF-alpha (cachectin)
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Synthesized, secreted from 1) MACROPHAGES, Endothelial cells, & Lymphocytes; involved in LOCAL & Systemic inflammation; Promotes bone resorption
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IL-1
(alpha= cell bound; beta= secreted) |
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Cox-1 function in the kidneys
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Maintains flow in compromised kidney
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