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16 Cards in this Set

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  • Back
May be cytokine responsible for activating T-cells in arthritis; produced mainly be macrophages
Increases B cell proliferation and immunoglobulin production and, therefore, may be involved in producing the rheumatoid factor (RF); enhances the formation of acute phase reactants from the liver and is involved in bone resorption
classified as a chemokine due to its powerful chemotactic properties for neutrophils and up-regulation of adhesion molecules. Secreted from macrophages and endothelial cells with specificity on neutrophils and less on monocytes and eosinophils. IL-1 and TNF are potent inducers of IL-8!!!!! Other examples of chemokines are MCP-1 (monocyte chemoattractant) and RANTES (regulated and normal T cell expressed and secreted) released from lymphocytes and attract monocytes, lymphocytes, eosinophils and basophils, BUT NOT neutrophils. Involved in different types of inflammation.
Anti-inflammatory Cytokines
IL-4, IL-10, IL-13
Also called lymphotoxin; released from T-lymphocytes and NK-cells
Preformed cellular-derived mediators
Histamine, Serotonin, Proteases (lysosomal enzymes)
Plasma derived mediators
complement, kinin, clotting (systems)
Confined to endothelial cells- bind to receptors on white cells
B2 receptor for bradykinin function to:
1. Smooth muscle contraction
2. Inc. Vas perm
3. Vasodilation
4. Stim. sensory nerve endings
5. Rel. Substance P
6. Degranulated Mast cells
B1 receptor for bradykinin function to:
1. Smooth muscle contraction
2. Bone resorption
3. Rel Pgs
4. Rel Interleukins & TNF
Fibrinopetides of the clotting system are converted from fibrinogen by thrombin to:
increase vascular perm, & are chemotatic
Increases formation of adhesion molecules
Factor Xa
increases vascular permeability
Produced from MACROPHAGES (also T-cells, NK cells, mast cells) promotes 1) Cartilage degradation & 2) stim. bone resoprtion
TNF-alpha (cachectin)
Synthesized, secreted from 1) MACROPHAGES, Endothelial cells, & Lymphocytes; involved in LOCAL & Systemic inflammation; Promotes bone resorption
(alpha= cell bound; beta= secreted)
Cox-1 function in the kidneys
Maintains flow in compromised kidney