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16 Cards in this Set
- Front
- Back
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What is the specific gravity of an exudate? Transudate?
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Exudate: SG > 1.020
Transudate: SG <1.012 |
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What are the leukocyte cellular events during chemotaxis?
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Margination, rolling, adhesion, transmigraiton
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Selectins are involved in what part of chemotaxis?
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Selectins in rolling
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Integrins are involved in what part of chemotaxis?
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Integrins in adhesion and transmigration
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Diapedesis is mediated by what integrins?
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PECAM-1, ICAM-1
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Name 2 opsins.
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IgG, C3
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What is defective in leukocyte adhesion deficiency (LAD) 1 and 2?
What is the phenotype of leukocyte adhesion deficiency (LAD)? |
LAD 1: Defect in beta chain of CD11/CD18 integrins results in inability to adhere
LAD 2: defect in sialyated oligosaccharide Phenotype: Recurrent bacterial infections without neutrophils (they can roll but not adhere). |
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What is the defect in chronic granulomatous disease?
What is the phenotype? |
Defect in NADPH oxidase system.
Phenotype: marked decrease in ability to kill micro-organisms with many granulomas |
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What is the defect in Chediak-Higashi syndrome?
What is the phenotype? |
Defect in chemotaxis and lysosomal degranulation into phagosomes.
Phenotype: oculocutaneous albinism, frequent bacterial infection (esp. S. aureus), and neuropathy |
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What microorganisms are people with defects in the membrane attack complex (C5-9) susceptible to?
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Encapsulated: Neisseria, Streptococcus, Hemophilus, Listeria
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Presence of C1 inhibitor causes what disease?
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Hereditary angioneurotic edema
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What is the defect in paroxysmal nocturnal hemoglobuinuria and what is the pathophysiology of disease?
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Defects in:
CD55: decay-accelerating factor (disrupts formation of C3 convertase) CD59: protectin (binds MAC which prevents binding of C9) |
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Cytokines:
IL-1 and TNF-alpha are made by what? TNF-beta is made by what? |
Macrophages: IL-1, TNF-alpha
T-cells: TNF-beta |
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Labile, stable, or permanent cells?
Epidermis Mucosal epithelium GI tract epithelium |
Labile
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Labile, stable, or permanent cells?
Hepatocytes Renal tubular epithelium Pancreatic acini Spleen |
Stable
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Labile, stable, or permanent cells?
Nerve cells Cardiac myocytes Skeletal muscle |
Permanent
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