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15 Cards in this Set
- Front
- Back
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PMN adhesion molecules?
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B2-integrins
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What activates adhesion molecules
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LTB4, C5a, IL-8
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What effect will catecholamines, Li, and CS have on adhesion molecules?
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Inhibits activation, therefore get increase # in peripheral blood
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Endothelial cell adhesion molecules?
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ICAM, VCAM
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What mediates activation of endothelial cell adhesion molecules?
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IL-1 and TNF
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Infant presents with severe gingivitis, poor wound healing, leukocytosis. What this the defect / disorder / other finding?
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LAD - AR disorder due to
1) B2-Integrin disorder (CD11a:CD18) Delayed seperation of umbilical cord (>1mo) - PMNs are impt in cord seperation 2) Selectin (that bind PMN) deficinecy |
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Where is the O2-dependent MPO system found?
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PMNs and monocytes, NOT macrophages
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Difference in DZ presentation between infection with Cat+ and Cat- organism in GCD?
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Cat+: NAPHD oxidase absent, therefore NO O2 to Superoxide conversion, therfore NO superoxide to H202 conversion by SOD. Since cat+, the organism will degrade the H202 before in can be combined with Cl by MPO to make bleach.
Cat-: Even rep burst absent, can still use h202 in cell + cl = bleach |
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O2 independent killing?
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Lactoferrin binds iron necessary for bacterial reproduction
Major basic protein from eosin that is toxic to helminths |
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Outline the metabolism of AA?
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Cell membrane phospholipids
(Phospholipase A2) AA 1.(5-lipoxygenase) LTC4 D4 E4 = vessel permeabil 2. (COX) PGG2 PGH2 PGE2 = pain, fever a. (Thromboxane synthase) TXA2 = Vasoconstriction b. (Prostacyclin synthase) PGI2 = Vasodilation |
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Role of fever in Hb-dissoc curve?
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R shift curve making more O2 available for Resp. burst / MPO killing
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Identify plasma cell on slide?
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Eccentric nucleus with perinuclear clearing
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G1 phase
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Mosat variable phase of celll cycle
Syn of RNA, protein, organelles, and cyclin D |
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G2 phase
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Syn of tubulin necessary for M phase
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Most critical phase in cell cycle?
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G1 to S phase
Controlled by RB and P53 |
