Infective Endocarditis

Front 1

What is Infective endocarditis?

Back 1

colonization of heart valves w/ microbiologic organisms

leading to

formation of friable, infected vegetations

and

frequently valve injury.

Front 2

Pathogenesis

Back 2

Bacteremia is a prerequisite for IE. They may derive from an infection elsewhere in the body; IV drug abuse; dental or surgical procedures; or micro-injuries to gut, urinary tract, oropharynx, or skin.

Front 3

Predisposing factors

Back 3

 Cardiac congenital anomalies (e.g. tight shunts, VSD, ASD)
 Previously damaged valves (e.g. rheumatic heart disease)
 Prosthetic valves
 Indwelling catheters
 Neutropenia
 Immunosuppressed states

Front 4

Compx: TYPES?

Back 4

Cardiac
Embolic
Renal

Front 5

Cardiac compx?

Back 5

Valvular insuff.
Stenosis
CF

Myocardial ring abscess +/- aortic/IV spetum perf.
--Suppurative pericarditis

(Artificial valves) Partial dehiscence + paravalvular leak

Front 6

Embolic compx?

Back 6

LEFT sided lesions:
-Brain: cerebral infarct, abscess, meningitis
-Heart: MI
-Spleen: abscess
-Kidneys: abscess

RIGHT sided lesions:
-Lungs: infarct, abscess, pneumonia

Front 7

Renal compx?

Back 7

Embolic Infarction

Focal + diffuse GLOMERULONEPHRITIS
due to trapping of Ab-Ag complexes

--> Haematuria, albuminuria + RENAL FAILURE

Multiple abscesses esp. w/ acute Staph.