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17 Cards in this Set
- Front
- Back
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M2 inhibitors are useful for influenza ___. Name em!
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influenza A
amantadine;rimantidine |
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Neuraminidase inhibitors are useful for influenza ___. Name em!
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influenza A and B
zanamivir (inhaled); oseltamivir (oral) |
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treatment of RSV (especially severe cases)
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RIBAVIRIN (guanosine analog)
- use aerosolized version to tx severe RSV infections in children - this drug alters nucleotide pools and mRNA formation |
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what are the 4 infections that RIBAVIRIN is useful for?
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RSV
HCV (with IFN-alpha) hantavirus (bunyaviridae) Lassa fever (arenaviridae) |
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adverse effects of ribavirin
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anemia, bronchospasm, contraindicated in pregnancy
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what are the treatments available for HSV (including encephalitis)?
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acyclovir (inhibits DNA polymerase --> chain termination, requires thymidine kinase)
HSV1>HSV2>VZV |
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tx for VZV (and also HSV)
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valacyclovir/famciclovir (greater oral bioavailability than acyclovir)
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tx for ALL CMV infections
What are the SEs for this drug? |
ganciclovir (SEs: neutropenia, thrombocytopenia)
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tx for CMV retinitis (in HIV and other immunocompromised pts)
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cidofivir/foscarnet
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what treats acyclovir-resistant HSV infections?
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foscarnet (SEs: nephrotoxicity, electrolyte abnormalities)
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what tx can be used for CMV in AIDs pts when all other therapies have failed?
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Fomivirsen
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how do you treat HBV?
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IFN-alpha with nucleoside/nucleotide analogues
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what does IFN-alpha do? what is its modification to prolong antiviral effects?
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induces antiviral states via induction of cellular genes
may be pegylated to prolong antiviral effects ("peg-interferon") |
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what are the uses of IFN-alpha
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HBV (with nucleoside/nucleotide analogues)
HCV Kaposi's sarcoma (HHV 8) Condyloma acuminata (HPV) |
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mechanism of nucleoside/nucleotide analogues
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reverse transcriptase and/or DNA polymerase inhibitors (useful for HBV)
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name some nucleoside/nucleotide analogues
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lamivudine
adefovir dipivoxil entecavir telbivudine (can cause myopathy) tenofivir (best one, i think) |
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what do you use to tx genital warts (HPV)?
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imiquinod + IFN-alpha
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