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5 Cards in this Set
- Front
- Back
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fimbriae |
-fresh isolates express fimbriae -subcultures may not express fimbriae -increase adherance to host cell and saliva coated hydroxyapatite |
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Ema A |
-very large surface protein -binds to type 1 collagen -important in endocarditis and host cell attachment |
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LPS |
-potent LPS which can act as B-cell mitogen -produces hemorrhagic necrosis of skin -stimulates bone resorption in vitro -aggregates platelets -activates macrophages(tissue inflammation) -inflammation leading to destruction of the periodontal tissues |
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leukotoxin (Ltx A) |
-A.a expresses Ltx A that kills human neutrophils and monocytes -very quick and specific, other human cells like leukocytes not affected by Ltx A -the leukotoxin inserts in target cell membranes, resulting in lysis of the cell (does not form pores) -an RTX toxin (a group of exotoxins produced by gram - ) |
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cytolethal distending toxin |
-mechanism of action is by arresting T-cells during blastogenesis which then induces apoptosis -the combined effects of Ltx and Cdt are likely profound in the periodontal pocket and may promote significant immune dysfunction |
