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9 Cards in this Set
- Front
- Back
Thiopentol: Mech of action, class, category
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Category: Induction agent, sedative
Class: ultra-short acting barbiturate Mech of action: Potentiation of GABA-A receptor (a ligand-gated Cl- channel) --> allows more Cl- to come into cell (R remains open longer)--> hyperpolarization |
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Thiopentol: metabolism/excretion, Desired effects, side effects, indications
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Metabolism: redistribution is rapid, metabolism is SLOW
desired effects:CNS depression side effects: (1)Tissue necrosis if perivascular (infiltrate lidocaine+saline) (2) arrhythomgenic-ventricular bigeminy (3) rough recovery, animal hungover (4) resp depression Indications: eval laryngeal fxn |
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Thiopentol: Contraindications, Comments
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Greyhounds--slow metabolism of thiopentol! very slow recovery
Cardiac dz-increases sensitivity comments: (1) obesity prolongs drug metabolism (2) cannot give mult doses -cumulative effect (3) rapid redistribution--animal awakens from 1st dose in 10-15 min |
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Propofol: Mech of action, class, category
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Mech: Potentiate GABA-A receptor (ligand-gated Cl- channel)
class: substituted phenol category: induction agent, sedative, hypnotic |
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Propofol: Metabolism/excretion, desired effects, side effects, indications for use
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met: rapid redistrib, rapid met
desired effects: CNS depression (rapid alert recovery, minimal hangover) side effects: HYPOTENSION (d/t vasodilation) Apnea (preoxygen patient to avoid) Myoclonus and paddling |
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Propofol: indications, contraindications, comments
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indications: none
contraindications: decreases CO, CP dz! comments: Awaken from first dose in 10-15 min d/t redistribution, can give mult doses or CRI d/t rapid met. Supports growth of bacteria/yeast--keep max 12 hrs. Cirrhosis and dec GFR minimally affect metabolism (RBC, lung drug met take over) |
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Etomidate: category, class, mech
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Mech: potentiate GABA-A R
category: induction agent, hypnotic class: ? |
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Etomidate: metabolism, desired effects, side effects, indications
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Metabolism: rapid (hepatic) w/ rapid redistribution
desired effects: CNS depression side effects: Adrenocortical suppression (PseudoAddisonian) px w. saline, increase K+ avaliable (insulin, glucose, saline, Ca), dexamethasone hemolysis myoclonus, vocalization Indications: SEVERE CO disturbed patients (b/c has minimal CV effects) |
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Etomidate: contraindications, comments
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contraindications: cats (propylene glycol carrier), Adrenocortical insufficiency or suppression (from chronic dz)
painful to inject! |