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19 Cards in this Set
- Front
- Back
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What type of agent are macrolides? |
Bacteriostatic |
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Indication for macrolides |
Used mostly for respiratory infections |
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Two examples of macrolides |
Erythromyin and clarithromycin |
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MOA of macrolides |
Reversibly bind to 50S ribosomal subunit which inhibits protein synthesis |
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Side effect of macrolides |
QT prolongation - shouldn't be taken with other drugs with the same effect |
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What type of agents are aminoglycosides? |
Bactericidal |
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One example of an aminoglycoside |
Gentamicin |
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Activity range of gentamicin |
Gram-negative |
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Indication of gentamicin |
Only used in hospital for serious infections |
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MOA of aminoglycosides |
Irreversibly inhibits 30S subunit of the bacterial ribosome, interrupting protein synthesis |
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What type of compound is bacitracin? |
Peptide antibiotic |
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MOA of bacitracin |
Inhibits recycling of bactoprenol, which is an enzyme involved in flipping of lipids in peptidoglycan biosynthesis |
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What type of compounds are vancomycin and teicoplanin? |
Glycopeptides |
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What type of agent are vancomycin and teicoplanin? |
Bactericidal |
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Activity range and indication of vancomycin and teicoplanin? |
Only for gram-positive and used for treatment of serious infection (e.g. MRSA) |
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MOA of vencomycin and teicoplanin |
Prevent addition of murein monomers in peptidoglycan biosynthesis |
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Activity range of polymyxins |
Only effective against gram-negative bacteria |
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One example of a polymyxin |
Colistin |
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MOA of polymyxins |
Binds to membrane phospholipids and changes permeability to potassium and sodium ions, resulting in lysis |
