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23 Cards in this Set
- Front
- Back
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IL-1
secreted by? major function? |
- macrophages
- fever (pyrogen), causes acute inflammation |
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IL-2
secreted by? major function? |
- Th (helper TCells)
- stimulates TCell growth |
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IL-3
secreted by? major function? |
- activated TCells
- stimulates bone marrow stem cells |
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IL-4
secreted by? major function? |
- Th2 (helper TCells)
- stimulates IgE class switching & BCell growth |
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IL-5
secreted by? major function? |
- Th2 (helper TCells)
- stimulates IgA class switching & BCell growth |
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IL-6
secreted by? major function? |
- Th (helper TCells), macrophages
- acute phase reactants (like C-Reactive Protein) |
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IL-8
secreted by? major function? |
- macrophages
- major chemotactic factor for neutrophils |
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IL-10
secreted by? major function? |
- Treg (regulatory TCells)
- inhibits action of TCells note- IL-10 & TGF-Beta = anti-inflammatory |
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IL-12
secreted by? major function? |
- BCells, macrophages
- activates NK cells and Th1 cells |
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IFN-y
secreted by? major function? |
- Th1 (helper TCells)
- stimulates macrophages and NK cells, increasing Th1 response |
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TNF-a
secreted by? major function? |
- macrophages
- increases IL2 receptor synthesis and BCell proliferation |
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TNF-b
secreted by? major function? |
- activated TCells
- increases IL2 receptor synthesis and BCell proliferation (same as TNF-a) |
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C3b
secreted by? major function? |
- n/a
- opsonization |
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C3a, C5a
secreted by? major function? |
- n/a
- anaphylaxis |
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C5a
secreted by? major function? |
- n/a
- neutrophil chemotaxis |
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Prostoglandins (2 of them)
secreted by? major function? |
- n/a
- PGE2: vasodilation, pain, fever - PGI2: OPPOSITE ThromA2 = vasodilation, platelet inhibition |
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Thromboxane A2
secreted by? major function? |
- n/a
- OPPOSITE PGI2 = vasoconstrction, platelet aggregation |
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Leukotrienes (2+ of them)
secreted by? major function? |
- n/a
- LTB4: chemotaxis - others: vasoconstriction, bronchoconstriction, increased vessel premeability |
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Bradykinin
secreted by? major function? |
- n/a
- vasodilation, increased vessel permeability, pain |
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Histamine
secreted by? major function? |
- Mast cells
- vasodilation of arterioles, increased vessel permeability of venules |
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Nitric Oxide (NO)
secreted by? major function? |
- endothelial cells
- vasodilation |
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Serotonin
secreted by? major function? |
- mast cells, platelets
- vasodilation, increased vessel permeability |
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Hageman Factor (aka factor XII)
secreted by? major function? |
- n/a
- initiates multiple pathways: bradykinin, clotting cascade, fibrin cascade, complement |
