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48 Cards in this Set
- Front
- Back
What are the cell cycle specific oncologic drugs
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antimetabolites (MTX, 5FU, 6MP), etoposide, bleomycin, vinca alkaloids, paclitaxel
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What are the cell cycle Nonspecific oncologic drugs?
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alkylating agents and antibiotics (dactinomycin, doxorubicin, bleomycin)
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____is an S-phase-specific anti-metabolite that is an folic acid analog that inhibits dihydrofolate reducate decreasing dTMP(thymidine and purines) and decreaing DNA/prtein synthesis.
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Methotrexate
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____is an S-phase-specific anti-metabolite that is a pyrmidine analog which complexed to folic acid, inhibiting thymidylate synthase, decreasing dTMP and decreasing DNA/protein synthesis
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5-Fluorouracil (5-FU)
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Myelosuppression by methotrxate is reversible with ____
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leucovorin (folinic acid) rescue
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Which drug blocks purine synthesis and is used to treat leukemias, lymphomas (not CLL or Hodgkins)
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6-mercaptopurine (6-MP)
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Which drug alkylates DNA and is used to treat CML?
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Busulfan
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Which drug inhibits DNA polymerase and is used to treat AML?
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cytarabine
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This drug used to treat Leukemias and Lymphomas is metaboilized by xanthine oxidase
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6-mercaptopurine (6-MP)
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Used to treat leukemias, lymphomas, choricarcinoma, sacromas, rheumatoid arthritis, psoriasis, and can be an abortifacient; it may lead to myelosuppression
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Methotrexate
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Used to treat colon cancer and other solid tumors, basal cell carcinoma (topically)
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5-Fluorouracil (5-FU)
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Myelosuppression by 5-FU is ______
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Not reversible with leucovorin (folinic acid) rescue
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This drug used to treat AML may lead to leukopenia, thrombocytopenia, megaloblastic anemia?
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cytarabine
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This drug used to treat CML may lead to pulmonary fibrosis and hyperpigmentation?
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Busulfan
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____is an alkylating agent acivated by liver that covalently x-links DNA at guanine N-7, and is used to treat non-hodgkin's lymphoma, breast/ovarian carcinomas
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cyclophosphamides
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____ alkylates DNA after bioactivation and can cross the BBB and treats brain tumors (glioblastoma multiforme)
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Nitrosoureas (Carmustine, lomustine, semustine, streptozocin)
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____acts like an alkylating agent, used to treat testicular, bladder, lung carcinomas
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Cisplatin
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This alkylating agent can cause myelosuppression and hemorhagic cystitis
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cyclophosphamides
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This combination of drugs is used to treat Hodgkin's and myelomas, sarcomas, and solid tumors (breast, ovary, lung)
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ABVD: Adriamycin, Bleomycin, Vinblastine, Dacarbazine
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____ and ___ noncovalently intercalate in DNA, creating breaks to decrease replication and transcription
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Doxorubicin (adriamycin) and daunorubicin
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____intercalates DNA.
____ induces free radical fromation which causes strand breaks |
Dactinomycin, Bleomycin
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Which drugs causes cardiotoxicity, alopecia, and myelosuppression?
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Doxorubicin (adriamycin)
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Which drug is used to trat oat cell carcinoma of the lung and prostate/testicular carcinoma?
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Etoposide
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This combination of drugs is used to treat lymphoma, CLL, Hodgkin's, Wilm's tumor, choriocarcinoma
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MOPP (Mustargen, Oncovin (Vincristine), Procarbazine (Matulane), Prednisone)
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Which glucocorticoid may trigger apoptosis and may even work on nondividing cells
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Prednisone
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This drug is a G2-phase specific inhibitor of Topisiomerase II, leaving double strand breaks in DNA following DNA replication
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Etoposide
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This drug used to treat testicular cancer and lymphomas may cayse pulmonary fibrosis, skin chnages, and minimal myelosuppression
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Bleomycin
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This drugs used as an immunosuppressant and in lymphomas may cause acne, osteoporosis, hypertension, peptic ulcers, hyperglycemia, psychosis?
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Prednisone
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____is an estrogen receptor mixed agonist/antagonist that blocks the binding of estrogen to ER+ cells.
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Tomoxifen/Raloxifene
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____is n M-phase-specific alkaloid that binds to tubulin and blocks polymerization of microtubules, preventing spindle formation
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Vincristine and Vinblastine
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____is an M-phase-specific agen that binds to tubulin and hyperstabilizes the polymerized microtubules, so that the mitotic spindle cannot break down
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Paclitaxel
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What drugs is used to treat breast cancer, but may increas the risk of endometrial carcinomas and hot flashes
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Tomoxifen
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Side-effects of Vinblastine include….
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VinBASTine BLASTs Bone Morraow, causing myelosuppression
Vincristine: neurotoxicity and paralutic ileus. |
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Side effects of Paclitaxel include….
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Myelosuppression and hypersensitivity
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This drug binds to cyclophilins, blocking differentiation and activation of T cells mainly by inhibiting IL2 production
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cyclosporine
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This antimetabolite derivative of 6-mercaptopurine interferes with the metabolism and synthesis of nucleic acid, therefore toxic to proliferating lymphocytes
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azathioprine
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This potent immunosuppressive drug binds to the FK-binding protein and inhibits secretion of IL2 and other cytokines
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tacrolimus (FK506)
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This drug is used to suppress organ rejection after transplantation, but may predispose patient to viral infections and lymphoma
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cyclosporine
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Azaothioprine is used to in what setting?
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Kidney transplants, autoimmune disorders (glomerulonephritis, hemolytic anemia)
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Recombinant Cytokine- Aldesleukin (interleukin-2) is used for?
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Renal cell carcinoma, metastatic melanoma
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Recombinant Cytokine- Erythropoietin (epoetin) is used for?
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anemia, especially in renal failure
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Recombinant Cytokine- Filgrastim is used for?
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Recovery of Bone Marrow; it is a granulocyte colony stimulating factor
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Recombinant Cytokine- alpha interferon is used for?
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Hep B/C, Kaposi's sarcoma, leukemia, malgnant melanoma
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Recombinant Cytokine- beta interferon is used for?
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Multiple Sclerosis
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Recombinant Cytokine- gamma interferon is used for?
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Chronic Granulomatous disease
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Recombinant Cytokine- oprelvekin (interleukin11) is used for?
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Thrombocytopenia
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Recombinant Cytokine- sargamostim is used for?
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Recovery of Bone Marrow (it is a granulocyte-macrophage colony stimulating factor)
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Recombinant Cytokine- thrombopoietin is used for?
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Thrombocytopenia
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