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48 Cards in this Set

  • Front
  • Back
What are the cell cycle specific oncologic drugs
antimetabolites (MTX, 5FU, 6MP), etoposide, bleomycin, vinca alkaloids, paclitaxel
What are the cell cycle Nonspecific oncologic drugs?
alkylating agents and antibiotics (dactinomycin, doxorubicin, bleomycin)
____is an S-phase-specific anti-metabolite that is an folic acid analog that inhibits dihydrofolate reducate decreasing dTMP(thymidine and purines) and decreaing DNA/prtein synthesis.
____is an S-phase-specific anti-metabolite that is a pyrmidine analog which complexed to folic acid, inhibiting thymidylate synthase, decreasing dTMP and decreasing DNA/protein synthesis
5-Fluorouracil (5-FU)
Myelosuppression by methotrxate is reversible with ____
leucovorin (folinic acid) rescue
Which drug blocks purine synthesis and is used to treat leukemias, lymphomas (not CLL or Hodgkins)
6-mercaptopurine (6-MP)
Which drug alkylates DNA and is used to treat CML?
Which drug inhibits DNA polymerase and is used to treat AML?
This drug used to treat Leukemias and Lymphomas is metaboilized by xanthine oxidase
6-mercaptopurine (6-MP)
Used to treat leukemias, lymphomas, choricarcinoma, sacromas, rheumatoid arthritis, psoriasis, and can be an abortifacient; it may lead to myelosuppression
Used to treat colon cancer and other solid tumors, basal cell carcinoma (topically)
5-Fluorouracil (5-FU)
Myelosuppression by 5-FU is ______
Not reversible with leucovorin (folinic acid) rescue
This drug used to treat AML may lead to leukopenia, thrombocytopenia, megaloblastic anemia?
This drug used to treat CML may lead to pulmonary fibrosis and hyperpigmentation?
____is an alkylating agent acivated by liver that covalently x-links DNA at guanine N-7, and is used to treat non-hodgkin's lymphoma, breast/ovarian carcinomas
____ alkylates DNA after bioactivation and can cross the BBB and treats brain tumors (glioblastoma multiforme)
Nitrosoureas (Carmustine, lomustine, semustine, streptozocin)
____acts like an alkylating agent, used to treat testicular, bladder, lung carcinomas
This alkylating agent can cause myelosuppression and hemorhagic cystitis
This combination of drugs is used to treat Hodgkin's and myelomas, sarcomas, and solid tumors (breast, ovary, lung)
ABVD: Adriamycin, Bleomycin, Vinblastine, Dacarbazine
____ and ___ noncovalently intercalate in DNA, creating breaks to decrease replication and transcription
Doxorubicin (adriamycin) and daunorubicin
____intercalates DNA.
____ induces free radical fromation which causes strand breaks
Dactinomycin, Bleomycin
Which drugs causes cardiotoxicity, alopecia, and myelosuppression?
Doxorubicin (adriamycin)
Which drug is used to trat oat cell carcinoma of the lung and prostate/testicular carcinoma?
This combination of drugs is used to treat lymphoma, CLL, Hodgkin's, Wilm's tumor, choriocarcinoma
MOPP (Mustargen, Oncovin (Vincristine), Procarbazine (Matulane), Prednisone)
Which glucocorticoid may trigger apoptosis and may even work on nondividing cells
This drug is a G2-phase specific inhibitor of Topisiomerase II, leaving double strand breaks in DNA following DNA replication
This drug used to treat testicular cancer and lymphomas may cayse pulmonary fibrosis, skin chnages, and minimal myelosuppression
This drugs used as an immunosuppressant and in lymphomas may cause acne, osteoporosis, hypertension, peptic ulcers, hyperglycemia, psychosis?
____is an estrogen receptor mixed agonist/antagonist that blocks the binding of estrogen to ER+ cells.
____is n M-phase-specific alkaloid that binds to tubulin and blocks polymerization of microtubules, preventing spindle formation
Vincristine and Vinblastine
____is an M-phase-specific agen that binds to tubulin and hyperstabilizes the polymerized microtubules, so that the mitotic spindle cannot break down
What drugs is used to treat breast cancer, but may increas the risk of endometrial carcinomas and hot flashes
Side-effects of Vinblastine include….
VinBASTine BLASTs Bone Morraow, causing myelosuppression
Vincristine: neurotoxicity and paralutic ileus.
Side effects of Paclitaxel include….
Myelosuppression and hypersensitivity
This drug binds to cyclophilins, blocking differentiation and activation of T cells mainly by inhibiting IL2 production
This antimetabolite derivative of 6-mercaptopurine interferes with the metabolism and synthesis of nucleic acid, therefore toxic to proliferating lymphocytes
This potent immunosuppressive drug binds to the FK-binding protein and inhibits secretion of IL2 and other cytokines
tacrolimus (FK506)
This drug is used to suppress organ rejection after transplantation, but may predispose patient to viral infections and lymphoma
Azaothioprine is used to in what setting?
Kidney transplants, autoimmune disorders (glomerulonephritis, hemolytic anemia)
Recombinant Cytokine- Aldesleukin (interleukin-2) is used for?
Renal cell carcinoma, metastatic melanoma
Recombinant Cytokine- Erythropoietin (epoetin) is used for?
anemia, especially in renal failure
Recombinant Cytokine- Filgrastim is used for?
Recovery of Bone Marrow; it is a granulocyte colony stimulating factor
Recombinant Cytokine- alpha interferon is used for?
Hep B/C, Kaposi's sarcoma, leukemia, malgnant melanoma
Recombinant Cytokine- beta interferon is used for?
Multiple Sclerosis
Recombinant Cytokine- gamma interferon is used for?
Chronic Granulomatous disease
Recombinant Cytokine- oprelvekin (interleukin11) is used for?
Recombinant Cytokine- sargamostim is used for?
Recovery of Bone Marrow (it is a granulocyte-macrophage colony stimulating factor)
Recombinant Cytokine- thrombopoietin is used for?