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9 Cards in this Set
- Front
- Back
what are the major side effects of cyclosporin?
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NEPHROTOXICITY, hypertension, hepatotoxicity, GI toxicity, behavioral disturbances, increase risk of infection
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How does tacrolimus work?
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it inhibits T cell activation like cyclosporin with similar side effects except it also has neurologic side effects
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how does sirolimus work?
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it inhibits the targets of rapamycin [tor] signalling, T cell activation, effector phase... basically inhibits response to IL-2
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how do gluccocorticoids work and what are their side effects?
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they are antiproliferatives mainly, they also affect lymphocyte activation, chemotaxis in neutro's and monocytes, and reduce Ig levels. side effects include cushing's like syndrome, etc
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how does azathioprine work? side effects?
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it blocks purine synthesis (an antiproliferative). Side effects include bone marrow suppression, leukopenia, and thrombocytopenia
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how does cyclophosphamide work? side effects?
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it is anantiproliferative that alkylates DNA and inhibits cell division. side effects include hemorrhagic cystitis, severe bone marrow suppression.
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what drugs treat rheumatoid arthritis?
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NSAIDS, gluccocorticoids, methotrexate, or azothioprine
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how does methotrexate work and what are its side effects?
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it is an antiproliferative that inhibits dihydrofolate reductase. side effects: heptic fibrosis, cirrhosis, alopecia, bone marrow depression, increased infection risk
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Etanercept can also treat rheumatoid arthritis. How does it work and what are its side effects?
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it is a soluble version of TNF alpha receptor. It acts as a decoy to decrease signalling. flu like, acute hypersensitivity, erythema, reactivation of demyelinating diseases, lymphoproliferative rxn's.
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