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9 Cards in this Set

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  • Back
what are the major side effects of cyclosporin?
NEPHROTOXICITY, hypertension, hepatotoxicity, GI toxicity, behavioral disturbances, increase risk of infection
How does tacrolimus work?
it inhibits T cell activation like cyclosporin with similar side effects except it also has neurologic side effects
how does sirolimus work?
it inhibits the targets of rapamycin [tor] signalling, T cell activation, effector phase... basically inhibits response to IL-2
how do gluccocorticoids work and what are their side effects?
they are antiproliferatives mainly, they also affect lymphocyte activation, chemotaxis in neutro's and monocytes, and reduce Ig levels. side effects include cushing's like syndrome, etc
how does azathioprine work? side effects?
it blocks purine synthesis (an antiproliferative). Side effects include bone marrow suppression, leukopenia, and thrombocytopenia
how does cyclophosphamide work? side effects?
it is anantiproliferative that alkylates DNA and inhibits cell division. side effects include hemorrhagic cystitis, severe bone marrow suppression.
what drugs treat rheumatoid arthritis?
NSAIDS, gluccocorticoids, methotrexate, or azothioprine
how does methotrexate work and what are its side effects?
it is an antiproliferative that inhibits dihydrofolate reductase. side effects: heptic fibrosis, cirrhosis, alopecia, bone marrow depression, increased infection risk
Etanercept can also treat rheumatoid arthritis. How does it work and what are its side effects?
it is a soluble version of TNF alpha receptor. It acts as a decoy to decrease signalling. flu like, acute hypersensitivity, erythema, reactivation of demyelinating diseases, lymphoproliferative rxn's.