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12 Cards in this Set
- Front
- Back
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Azathoprine MOA and toxicities
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Purine agonist
Known mutagen and teratogen bone marrow suppression, GI distress, pancreatitis, and hepatotoxicity |
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Cyclophasphamide
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alkylating prodrug
myyelosuppression, gastroenterocolitic, alopecia, hemorrhagic cystitis |
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Cyclosporine
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inhibits lymphocyte proliferation.
GI, gingivial hyperplasia |
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Dapsone
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Folic acid inhibition
hepatotoxicity, hemolytic anemia, thrombocytopenia, neutropenia, GI, neuropathy, and cutaneous drug eruptions, carcinogen |
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Glucocorticoids
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Decrease gene expression effecting neutrophil trafficking, suppress macrophage function, lowered lymphocyte activity
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Methotrexate
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inhibits folic acid, S-phase inhibitor
GI, mucosal sloughing, stomatitis, hematopoietic toxicity, hepatopathy, renal tubular necrosis, alopecia, depigmentation pulmonayr inflitrates |
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Mycophenolate
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Inhibits purine synthesis enzymes - decreased lymphocyte proliferation
GI |
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Tacrolimus
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Calcineurin inhibitor, inhibits T-cell induction
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Calcineurin normally inhibits _____ allowing it to ______
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NFAT
move to nucleus and induce IL-2 |
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Calcineurin inhibitors
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cyclosporine
tacrolimus |
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Anti-proliferative - cytotoxic
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cyclophsophamide, chlorambucil
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Antimetabolites
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Azathioprine
Mycophenolate |
