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9 Cards in this Set
- Front
- Back
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anti-thymocyte globulin
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1. lymphopenia > 1yr
2. CRS |
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Anti-CD3
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1. muromonab, OKT3
2. decrease T cells week 3. CRS |
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Anti-CD52
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1. alemtuzamab
2. most potent 3. CD4 and CD8 for 3 yrs 4. B cells for many months 5. CRS |
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anti-cd25
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1. daclizumab, basiliximab
2. block IL2 via alpha subunit 3. cd25 expressed activated T cells |
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calcineurin inhibitors
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1. decrease IL2 inhibits G1-S in T cells
2. nephrotoxicity, neurotoxicity, diabetes, and HUS 3. anton syndrome |
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cell cycle inhibitors
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1. azathiopurine: prodrugs 6MP, purine analog
2. mycophenolate: decrease inosine monophosphate dehydrogenase to decrease purine synthesis 3. both lymphopenia |
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mTOR
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1. xenobiotic inhibits mTOR protein kinase
2. also bind FKBP12 prevent G1-S 3. impaired wound healing 4. sirolimus and everolimus |
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cyclosporin
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1. calcineurin inhibitor
2. binds cyclophilin to decrease IL2 and G1-S 3. hirsutism, gum hyperplasia |
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tacrolimus
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1. calcineurin inhibitors
2. binds FKBP12 decrease IL2 and G1-S 3. new onset diabetes |
