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23 Cards in this Set
- Front
- Back
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binds to cyclophilins
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cyclosporine
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complex blocks the differentiation and activation of t cells by inhibiting calcineurin, preventing production IL-2 and its receptor
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cyclosporine
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suppresses organ rejection after transplantation and selection autoimmune disorders
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cyclosporine
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binds to FK binding protein, inhibiting secretion of IL2 and other cytokines
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tacrolimus fk506
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used as a potent immunosuppresive used in organ transplant recipients
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tacrolimus fk506
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antimetabolite precursor of 6 mercapto purine that interferes with the metabolism and synthesis of nucleic acids.
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azathioprine
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toxic to proliferating lymphocytes
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azathioprine
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used for kidney transplantation, autoimmune disorders including glomerulonephritis and hemolytic anemia
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azathioprine
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monoclonal antibody that binds to CD3 (epsilon chain) on surface of T-cells. blocks cellular interaction with cd protein chain responsible for t-cell signal transduction
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muromonab-CD3 (okt3)
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used for immunosuppression after kidney transplant
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muromonab-CD3 (okt3)
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sirolamus (rapamycin)
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binds to mTOR. inhibits t-cell proliferation in response to IL-2
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immunosuppression after kidney transplantation in combo with cyclosporine and corticosteroids
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sirolamus (rapamycin)
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inhibits de novo guanine synthesis and blocks lymphocyte production
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mycophenolate mofetil
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monoclonal antibody with high affinity for IL-2 receptor on activated t-cells
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daclizumab
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aldesleukin
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recombinant IL2, used for renal cell carcinoma, metastatic melanoma
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erythropoetin
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epoetin, used in anemias especially in renal failure.
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filgrastim
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granulocyte colony stimulating factor. used for recovery of bone marrow
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sargramostim
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granulocyte -macrophage colony stimulating factor. used for recovery of bone marrow
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alpha interferon
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hep b, hep c, kaposi's sarcoma, leukemias, malignant melanoma
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beta interferon
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MS
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gamma interferon
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used for chronic granulomatous disease
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oprelvekin
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IL-11. used for thrombocytopenia
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thrombopoetin
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used for thrombocytopenia.
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