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21 Cards in this Set
- Front
- Back
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Cyclosporine
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Mechanism- Binds to cyclophilins and blocks the differentiation and activation of T-cells by inhibiting calcineurin (prevents production of IL-2 and IL-2R)
Use- Supresses organ rejection after transplantation, autoimmune disorders Toxicity- predisposes patients to viral infections and lymphoma; nephrotoxic (prevent with mannitol diuresis) |
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Tacrilomus (FK506)
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Mechanism- Binds FK-binding protein, inhibiting the secretion of IL-2 and other cytokines.
Use- Organ transplant Toxicity- Nephrotoxicity, peripheral neuropathy, hypertension, pleural effusion, hyperglycemia |
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Sirolimus (rapamycin)
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Mechanism- Binds mTOR. Inhibits T-cell proliferation in response to IL-2
Use- Kidney transplant in combination with Cyclosporin and steroids Toxicity- Hyperlipidemia, thrombocytopenia, leukopenia |
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Daclizumab
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Mechanism- mAb for IL-2
Use- Prevent acute rejection of renal transplant |
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Azothioprine
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Mechanism- Antimetabolite precursor of 6-MP that interferes with the metabolism and synthesis of nucleic acid (toxic to proliferating lymphocytes)
Use- Kidney transplant, autoimmune (GN, hemolytic anemia) Toxicity- BM suppression, 6-MP is metablized by xanthine oxidase so toxic effects if using allopurinol |
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Muromonab-CD3 (OKT3)
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Mechanism- mAb to CD3 epsilon chain on the surface of T-cells. Blocks cellular interaction with CD3R responsible for T-cell signal transduction.
Use- Immunosuppression after kidney transplant to prevent acute rejection. Toxicity- Cytokine release syndrome, hypersensitivity |
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Aldesleukin
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IL-2
Use- RCC, metastatic melanoma |
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Erythropoietin
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Anemias (renal failure) or chemo
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Filgrastim
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G-CSF
Recovery of BM |
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Sargramostim
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G-CSF
Recovery of BM |
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alpha-interferon
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HBV, HCV, Kaposi's, leukemias, malignant melanoma
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beta-interferon
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MS
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gamma-interferon
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chronic granulomatous disease
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Oprelvekin
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IL-11
Thrombocytopenia |
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Thrombopoietin
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Thrombocytopenia
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Digoxin Immune Fab
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Antidote for digoxin toxicity
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Infliximab
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mAb to TNF-a; Used in Crohn's, RA, psoriatic arthritis, ankylosing spondylitis
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Adalimumab
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mAb to TNF-a; Used in Crohn's, RA, psoriatic arthritis
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Abciximab
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mAb to glycoprotein IIb/IIIa; Used to prevent cardiac ischemia in unstable angina and in patients treated with PCI
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Trastuzumab (herceptin)
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mAb to erb-B2; used in patients with HER-2 overexpressing breast cancer
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Rituximab
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mAb to CD20; used for B-cell NHL
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