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31 Cards in this Set
- Front
- Back
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Established Rejection Rx
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gluccocorticoids in high pulse
muronmonab polyclonal antilumphocytic (antithymocyte) |
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Maintenance
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calcineurin inhibitor
gluccocorticoids mycophentolate mofetil = cytotoxic drug |
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depletion of lymphocytes
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antibodies
cytotoxic |
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prevntion of antigen recognition byAPC
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monoclonal Ab
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inhibition of production of proinflammatory cytokine
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gluccocorticoids
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prevention of t cell activation and il2 production
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antibodies
calcineurin inhibitors |
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block proliferation of t and b cells
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antibodies
cytotoxic drugs gluccocorticoids mTOR inhibitors |
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cytokine release syndrome
inhibits what? |
muromonab
CD3 |
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fxn of muromonab
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depletes t cells of donor
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antiCD25 examples
fxn? |
daclizumab; basiliximab
binds il-2; specific for active NOT RESTING t cells; blocks proliferation prophylaxic for acute rejction |
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hepatoxicity
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azathiprine
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nephrotoxicity
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cyclosporine
tacrolimus |
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diabetes
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tacrolimus
prednisone |
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gi disorders
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basiliximab
daclizumab mycophenotlate mofetil |
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thrombocytopenia
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sirolimus; aza
(cytotxic) |
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dose dependent hyperlipidemia
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sirolimus
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bone marrow suppression
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aza
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do not give what drug to azathioprine
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allopurinol
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aza and mycophentolate mofetil fxn
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inhibit purine synthesis
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watch for lymphomas in what 2 drug classes
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anti-TNF
calcineurin inhibitors |
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used for autoimmune
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aza
cyclosporine |
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used for kidney
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aza
muromonab sirolimus |
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infliximab
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humanized monoclonal AB prevents binding to receptor TNF
RA Crohns |
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adalimumab
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TNF Ab
recombinant |
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name the other 2 anti tnf ab
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golimumab
etanercept (ligand binding only no ab) |
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side effects of aza
|
gi
hepatitis bone marrow |
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minocycline fxn
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antibiotic
mild help can cause drug induced lupus |
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cyclophosphamide
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cross links DNA
risk infection ; malignancy |
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rituximab
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anti CD20
depletes b cells ; RA not responsive to methotrexate |
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anakirinia
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recominant block 1l-1 Receptor
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abatacept
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fusion of ctla-4 to igG1
prevents t cell activation second line for severe RA |
