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21 Cards in this Set
- Front
- Back
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What is cyclosporine used for?
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Preventing organ rejection
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How does cyclosporine work?
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Suppress the production of IL-2
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What are the adverse effects of cyclosporine?
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Nephrotoxicity
Infection Hypertension Tremor Hirutism |
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How is nephrotoxicity measured?
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BUN (Blood Urea Nitrogen) and Serum Creatinine
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What is Tacrolimus used for?
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Preventing Kidney or Liver Rejection
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Tacrolimus is (more/less) powerful than Cyclosporine.
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More
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NSAIDs can be used with Tacrolimus and Cyclosporine.
T or F |
False
NSAIDs are nephrotoxic |
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How does Tacrolimus work?
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Suppress the production of IL-2
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What is Sirolimus used for?
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Prevention of Kidney Transplant Rejection
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What Calcineurin drug raises triglyceride and cholesterol levels?
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Sirolimus
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Glucocorticoids have multiple effects on the immune system.
T or F |
True
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How do cytotoxic drugs work?
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Killing B and T lymphocytes that are dividing (non-specific)
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What are the three non-specific cytotoxic drugs?
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Azathioprine
Cyclophosphamide Methotrexate |
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What is the only cytotoxic drug specific to B and T cells?
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Mycophenolate Mofetil
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What are the adverse effects of the cytotoxic drugs?
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Bone Marrow Suppression
GI effects Reduced fertility Alopecia (hair loss) |
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Cytotoxic drugs are the first line immunosuppresants.
T or F |
False
Glucocorticoids and Calcineurin inhibitors are the first line therapy. |
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What is Muromonab-CD3?
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Antibody that binds to the CD3 site on the T-cell
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How does basiliximab and daclizumab work?
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Antibody that binds the the IL-2 receptor on the T lymphocytes
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What are basiliximab and daclizumab used for?
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Preventing kidney transplant rejection
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What is Rh0 (D) Immune Globulin used for?
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Prevent the development of antibodies to Rh 0 (D) in negative women with a positive child
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The adverse effects of Tacrolimus are similar to which drug?
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Cyclosporine
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