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21 Cards in this Set

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What is cyclosporine used for?
Preventing organ rejection
How does cyclosporine work?
Suppress the production of IL-2
What are the adverse effects of cyclosporine?
Nephrotoxicity
Infection
Hypertension
Tremor
Hirutism
How is nephrotoxicity measured?
BUN (Blood Urea Nitrogen) and Serum Creatinine
What is Tacrolimus used for?
Preventing Kidney or Liver Rejection
Tacrolimus is (more/less) powerful than Cyclosporine.
More
NSAIDs can be used with Tacrolimus and Cyclosporine.
T or F
False
NSAIDs are nephrotoxic
How does Tacrolimus work?
Suppress the production of IL-2
What is Sirolimus used for?
Prevention of Kidney Transplant Rejection
What Calcineurin drug raises triglyceride and cholesterol levels?
Sirolimus
Glucocorticoids have multiple effects on the immune system.
T or F
True
How do cytotoxic drugs work?
Killing B and T lymphocytes that are dividing (non-specific)
What are the three non-specific cytotoxic drugs?
Azathioprine
Cyclophosphamide
Methotrexate
What is the only cytotoxic drug specific to B and T cells?
Mycophenolate Mofetil
What are the adverse effects of the cytotoxic drugs?
Bone Marrow Suppression
GI effects
Reduced fertility
Alopecia (hair loss)
Cytotoxic drugs are the first line immunosuppresants.
T or F
False
Glucocorticoids and Calcineurin inhibitors are the first line therapy.
What is Muromonab-CD3?
Antibody that binds to the CD3 site on the T-cell
How does basiliximab and daclizumab work?
Antibody that binds the the IL-2 receptor on the T lymphocytes
What are basiliximab and daclizumab used for?
Preventing kidney transplant rejection
What is Rh0 (D) Immune Globulin used for?
Prevent the development of antibodies to Rh 0 (D) in negative women with a positive child
The adverse effects of Tacrolimus are similar to which drug?
Cyclosporine