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11 Cards in this Set
- Front
- Back
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Levamisole
uses? adverse effects? |
-antiparasitic that stimulates T-cells; can tx after surgical resection from colon cancer and tx nephrotic syndrome
-neutropenia, anemia, thrombocytopenia, agranulocytosis encephalopathy assoc with demyelination |
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BCG (bacillus calmette guerin)
uses? |
non-specific immunostimulator
-intravesical therapy of bladder cancer (introduced directly into bladder) -known to inhibit TNFa production |
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Interferon alpha
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cytokine that enchances MHC class 1 and dec MHC class 2
-tx hairy cell leukemia, hep B/C, cancer tx for malignant melanoma and leukemias, condyloma acuminatum (genital warts) |
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Interferon beta 1a and beta 1b
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approved for MS
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Interferon gamma b
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chronic granulomatous dz, activates macrophages
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Aldesleukin
how does it work? uses? 2 adverse effects? |
-recombinant form of IL2 that promotes lymphoid cell differentiation into cytotoxic cells and activates NK cells
-adjunct in metastatic renal cell carcinoma, can tx metastatic melanoma -serious cardiovascular toxicity, and capillary leak syndrome |
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Oprelvekin
what is it? (derived from?) uses? |
-recombinant form of human IL-11 (derived from altered E.coli)
-thrombocytopenia (stimulates platelet formation) |
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Filgastrim (G-CSF)
what is it? uses? |
-granulocyte colony stimulating factor (made in E.coli), inc neutrophil production
-stimulates bone marrow recovery during cancer chemotherapy |
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Sagramostim (GM-CSF)
what is it? uses? 3 major adverse effects? |
-non-lineage specific hematopoetic agent that sitmulates both granulocytes and macrophages
-DOES ALOT promotes myeloid recovery, given during BM transplant, tx neutropenia -heart failure, pulmonary edema, yeast hypersensitivity (can also cause bone pain due to hypercellulitis) |
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Epoetin alpha (erythropoetin)
what is it? uses? 2 concerns? |
-recombinant human GF to stimulate erythroid precursors-erythropoesis
-surgery, tx anemia, cancer chemo, prematurity, renal dz -heart and liver toxicity with long term use |
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Thrombopoetin
what is it? uses? |
-myeloid cytokine GF analogous to erythropoietin, G-CSF, GM-CSF (recombinant human and fusion protein-GM-CSF+IL3)
*selectively stimulates megakaryocytopoiesis -can tx anemia, neutropenia, and thrombocytopenia assoc with high dose chemo (fusion protein); human thrombopoietin is used to accelerate platelet recovery |
