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24 Cards in this Set
- Front
- Back
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what is the stem cell marker
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cd34
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what are three myeloid markers
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cd13, cd33, myeloperoxidase
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what are 3 lymphoid markers
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cd10, T and B cell markers, TdT
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AML MO expresses
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cd13, cd33
myeloperoxidase negative - no Auer Rods |
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AML M1
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CD13, myeloperoxidase positive
without maturation beyond myeloblast |
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AML M2
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CD13, myeloperoxidase pos (AUER RODS!!!!!)
maturation - full range of granulocyte precurors |
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AML M3
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Acute promyelocytic leukemia
AUER RODS!!!! age 35-40 |
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AML M4
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CD4, CD14, CD64, Cd13, myeloperoxidase,
Acute Myelomonocytic Leukemia |
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AML M5
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CD14, CD64, non-spec esterase, neg for myeloperoxidase
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AML M7
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CD41a -
Acute megakaryocytic leukemia |
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T cell antigens
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CD 3,4,5,7,8
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B cell antigens
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CD 10 (CALLA), 19, 20, 23
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granulocytes
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CD 13, 33, 15
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Monocytes
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CD 11c, 14, 64
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Activation marker
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CD30
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Blasts have
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CD34
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Lymphoblasts have
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TdT
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precursor B ALL/Lymphoblastic Lymphoma immunophenotype
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TdT, CD10, CD19, CD20, CD34
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what is immunophenotype for precursor T-cell lymphoblastic lymphoma
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CD34, CD3, CD7, CD10+/-, TdT
may co-express CD4 and CD8 VERY UNIQUE AND ONLY IN PRECUROS THYMOCYTES |
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what is immunophenotype for chronic lymphocytic leukemia/small lymphocytic lymphoma
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CD5, Cd19, Cd20, weak surface light chain restricion
CD10 neg. T-cell SLL uncommon |
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immunophenotype of follicular lymphoma
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cd10+, CD19, CD22, surface light chain
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what is immunophenotype of mantle cell lymphoma
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CD5, CD19, Cd20, surface light chain restriction, cyclin D1
Cd10 & 23 negative Translocation (11;14) |
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what is immunophenotype for diffuse large B cell lymphoma
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Cd19, Cd20, surface light chain restriction
Cd5, 1 negative 30% trans either 3q27 or t(14;18) |
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what is immunophenotype for Burkitt Lymphoma
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CD10, Cd19, Cd20, surface IgM w light chain restriction
Always have translocation involving c-MYC oncognene on chromosome 8 t(8;14), t(2;8), t(8;22) |
