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50 Cards in this Set
- Front
- Back
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during organ transplantation, when does the induction regimen begin?
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2-12 weeks before transplant
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what is a common regimen given in organ transplantation?
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cyclosporin + predinsolone + azathiaprine
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what is cyclosporin?
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a cyclic nonribosomal peptide
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what is the moa of cyclosporine?
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binds w/ cyclophilin --> inhibits calcineurin --> inhibits activation of Tcell transcription factor --> decrease IL-2, IL-3, INF-y
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what is the moa of tacrolimus?
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inhibits calcineurin -->IL-2, IL-3, INF-y
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when is cyclosporine used?
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psoriasis, atopic dermatitis, rheumatoid arthritis, keratoconjunctivitis sicca, ulcerative colitis
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how is cyclosporine administered?
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topical and systemically
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what are the adverse effects of cyclosporin?
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gum hyperplasia, numbness, tingling, nehprotoxicity, hepatotoxicity --> cholelithiasia, HTN, opportunistic infections, hyperglycemia
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what is an alternate to cyclosporin a?
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cyclosporin G and has less nephrotoxicity
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when is azathioprine used?
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organ transplant, autoimmune disease, RA, crohns, ulcerative colitis
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what is the moa of azathioprine?
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inhibits purine synthesis esp in leukocytes
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what are the adverse effects of azathioprine?
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nausea, rash, GI mucositis, marrow suppression
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what genetic polymorphism predisposes to adverse effects from azathioprine?
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polymorphisms in TPMT can lead to excessive drug toxicity
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when is azathioprine use cautioned?
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when used w/ allopurinol
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what other additional risks are associated w/ azathioprine?
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is a carcinogen and can increase risk of non-Hodgkins lymphoma, squamous cell carcinoma of skin, hepatobiliary carcinoma, mesenchymal tumor
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what is methotrexate?
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a folic acid analog that inhibits DHFR
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when is methotrexate used?
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RA, psoriasis, cancer
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what are the adverse effects of methotrexate?
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myelosuppression, GI, hemorrhagic enteritis, neurotoxicity, hepatotoxicity
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what is RHoD Ig?
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antibody preventing hemolytic disease of the newborn given to mother
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when is RHoD Ig given?
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w/in 72 hours of delivery
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what is the moa of infliximab?
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inhibits TNF alpha
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when is infliximab used?
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RA, chron's
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what is the moa of abciximab?
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inhibits GP IIb/IIIa on platelets
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when is abciximab used?
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to prevent coagulation
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what is the moa of rituximab?
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targets phosphoprotein CD20 on B lymphocytes
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when is rituximab used?
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non hodgkins lymphoma
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what is the moa of daclizumab?
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inhibits IL-2 on activated t cells
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when is daclizumab used?
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acute rejection of kidney transplants
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what is the moa of palivizumab?
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inhibits RSV protein
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when is palivizumab used?
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RVS infection in children
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what is the moa of basiliximab?
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inhibits IL-2 on activated t cells
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when is basiliximab used?
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acute rejection of kidney transplants
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what is the moa of etanercept?
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contains TNF receptor
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when is etanercept used?
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RA
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when is recombinant IL-2 used?
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renal cell carcinoma, metastatic melanoma
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what is the moa of recombinant IL-2?
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promotes lymphocyte differentiation and NKs
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when is recombinant IL-11 used?
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chemotherapy induced thrombocytopenia
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what is the moa of recombinant IL-11?
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inproves platelet function
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when is recombinant G-CSF used?
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chemotherapy induced neutropenia --> bone marrow recovery
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what is the moa of recombinant G-CSF?
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stimulates proliferation and differentiation of granulocytes
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when is recombinant GM-CSF used?
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BM recovery after transplant and after AML chemo
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what is the moa of recombinant GM-CSF?
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stimulates granulocytes and macrophages
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when is recombinant EPO used?
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anemia assoc w/ ch renal dysfunction, chemo or radiation induced
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what is the moa of recombinant EPO?
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stimulates RBC production
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when is recombinant INF-a used?
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in combo w/ chemo and radiation
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what is the moa of recombinannt INF-a?
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JAK-STAT pathway takes part in regulation of cellular responses to cytokines of proliferation and differentiation
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when is recombinant INF-b used?
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improves integrity of BBB in MS
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what is the moa of recombinant INF-b?
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has anti-inflammatory properties
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when is recombinant INF-y used?
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chronic granulomatosis disease
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what is the moa of recombinant INF-y?
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macrophage activaing factor, enhances TNF
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