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22 Cards in this Set
- Front
- Back
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Tacrolimus, cyclosporin, and sirolimus are not effect once what begins?
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rejection
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Mechanism of cyclosporine
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inhibits cytokine production by binding to cyclophilin and reducing calcineurin (reduces IL-1,IL-1 and IFNy)
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Mechanism of Tacrolimus
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inhibits cytokine production (binds to Fk-binding protein)
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Mechanism of sirulimus
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binds Fk binding protein blocking activation of T-cell cycle and inhibits response of IL-2 but doesn't alter production
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Which drugs don't seem to have much effect of increased infections?
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Tacrolimus, Cyclosporine, Sirolimus
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Azathioprine is converted to _______
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6-mercaptopurine (remember 1/4 if using allopurinol)
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Azathioprine inhibits T cells ______ B cells (less than or greater than)
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greater than
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Mycophenolate Mofetil mechanism of action and suppression effect
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inhibits purine syntheis, suppresses both B and T cells
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cyclophosphamide mechanism of action
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alkylating agent that irreversibly complexes DNA (greatest effect on B cells)
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Agent that causes bladder cystitis
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cyclophosphamide
reduce with hydration |
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methotrexate mechanism of action
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DHFR inhibitor
greatest effect on B cells |
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Mechanism of action for Thalidomide
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suppresses TNFalpha production
anti-angiogenic action |
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Etanercept mechanism of action
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recombinant human TNF receptor (binding site of the receptor)
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Drug used for acute transplant rejection
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anti-thymocyte globulin
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Mechanism of action for anti-thymocyte globulin
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cytotoxic Abs to surface T-cell antigens
Direct cytotoxicity (complement and cell mediated) blockage of remaining lymphocyte fxn |
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Pre-treatment used for anti-thymocyte globulin
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anti-histamines to reduce histamine release, acetaminophen and corticosteroids
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Cytokine release syndrome
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muromonab-CD3
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Infliximab is
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chimeric IgG1 Ab
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Must pre test for TB before using which drug?
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Infliximab
it can activate latent TB |
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Epoetin alpha increases
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RBC
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sargramostim increases
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WBC
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Bacillus Calmette Guerin can cause a patient to test positive for what?
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TB
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