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52 Cards in this Set
- Front
- Back
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what are the four drugs that limit lympocyte proliferation?
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azathioprine, mycophenolate mofetil, cyclophosphamide, tacrolimus
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what drug interacts with azathioprine?
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allopurinol
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what is mechanism of azathioprine?
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coversion to fraudulent nucletotide that stops purine synthesis
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which of the three antilymphocyte proliferation drugs is most specific for lymph? Why?
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Mycophenolate mofetil. inhibits de novo synthesis
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what is the name of transription factor that activates synthesizes IL-2?
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NFAT
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what is calcineurin?
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dephosphoylates NFAT and activates it.
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what are two drugs that inhibit calcineurin?
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cyclosporine and tacrolimus
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what are the three main drugs given to renal transplant pts.
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cyclosporine, glucocorticoids, bmab
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what two organs do you use tacrolimus for
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renal and liver
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where is azathiprine and mycophenolate motefil excreted
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urine
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where is cycolosporine and tacrolimus metabolized?
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liver,
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which 3 drugs can you not take with cyclosporine?
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amphtoerrecin, erythromycin, itracanazole
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FKBR-12 (2 drugs that bind to this)
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tacrolimus, sirolimus
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cycophilin
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cyclosporine
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what is mechanism of sacrolimus
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inhibits IL-2 stimulated T cell proliferation.
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what two transcrition factors does glucocorticoids act with?
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IKB-1 AP-1
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IKB-1
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binds with NFKB
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NFKB
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transcrition factor for many cytokines
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what 2 drugs can you give for transplant rescue?
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glucorticoid and muromonab
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what drug is anti-CD3 and kills all T cells?
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muromonab
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drug from rabbit T depleting capability
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antithymocyte globulin
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name two anti IL 2 receptors
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basilixmab, daclizumab
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antithymocyte globulin
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rabbit polyclonal serum with T cell depleting activity
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azathioprine
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fradulent nucleotide that inhibits purine sythesis. bone marrow suppression, contraindicated with allopurinol
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basilimixab
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anti-CD25 receptor
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etanercept
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rhemetoid arthritis
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glat. acetate
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MS
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imab
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Crohn's disease
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IFN beta
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MS
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IVIG
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MS
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nmab
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last resort for MS
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What four drugs for MS?
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IFNbeta, nmab, IVIG, glat. acetate
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2 Drugs that is invovled with IL-10 both used to treat MS
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glat. acetate, IFN betaa
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Drug used as last resort to treat MS, binds with alpha-4 integrin, preventing leukocyte migration into tissue
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nmab
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Only drug for Crohn’s disease
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imab
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2 drugs for TNF tumor necrosis factor
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imab, etanercept
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Which drug that binds to TNF treats rhemetoid arthritis?
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etanercept
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Which drug binds to CD11, involed with preventing leukocyte adhesion?
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emab
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which drug for psoriasis?
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emab
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How long after birth do you give anti-D(Rh antibody after birth to prevent susbesquent abortions?
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72 hours
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Anti CD25
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bmab and dmab
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ChronicGranDisease?
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IFN gamma
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Treat thrombocytopena
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IL-11
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cyclosporin
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translplant, suppresses IL-2 transcription, binds cycolophillin
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dmab
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renal transplants, anti CD25, prevents binding of IL-2
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emab
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psoriasis, inhibits leukocyte migration binding to CD 11
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muronab
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anti CD3 wipes out T cells
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mycophenolate mofeteil
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selective lymphocyte proliferation inhibitor, by binding to inosine monophosphatte dehrogenase
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prednisone
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anti AP, binds to IFK preventing NFKbeta
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sirolimus
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upstream binds FKBP, inhibits calcineurin, inhibits NFAT, inhibits IL-2
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tacrolimus
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binds FKBP, inhibits calcineurin, inhibits NFAT, inhibits IL-2
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IFN gamma
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CGD
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