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52 Cards in this Set

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  • Back
what are the four drugs that limit lympocyte proliferation?
azathioprine, mycophenolate mofetil, cyclophosphamide, tacrolimus
what drug interacts with azathioprine?
allopurinol
what is mechanism of azathioprine?
coversion to fraudulent nucletotide that stops purine synthesis
which of the three antilymphocyte proliferation drugs is most specific for lymph? Why?
Mycophenolate mofetil. inhibits de novo synthesis
what is the name of transription factor that activates synthesizes IL-2?
NFAT
what is calcineurin?
dephosphoylates NFAT and activates it.
what are two drugs that inhibit calcineurin?
cyclosporine and tacrolimus
what are the three main drugs given to renal transplant pts.
cyclosporine, glucocorticoids, bmab
what two organs do you use tacrolimus for
renal and liver
where is azathiprine and mycophenolate motefil excreted
urine
where is cycolosporine and tacrolimus metabolized?
liver,
which 3 drugs can you not take with cyclosporine?
amphtoerrecin, erythromycin, itracanazole
FKBR-12 (2 drugs that bind to this)
tacrolimus, sirolimus
cycophilin
cyclosporine
what is mechanism of sacrolimus
inhibits IL-2 stimulated T cell proliferation.
what two transcrition factors does glucocorticoids act with?
IKB-1 AP-1
IKB-1
binds with NFKB
NFKB
transcrition factor for many cytokines
what 2 drugs can you give for transplant rescue?
glucorticoid and muromonab
what drug is anti-CD3 and kills all T cells?
muromonab
drug from rabbit T depleting capability
antithymocyte globulin
name two anti IL 2 receptors
basilixmab, daclizumab
antithymocyte globulin
rabbit polyclonal serum with T cell depleting activity
azathioprine
fradulent nucleotide that inhibits purine sythesis. bone marrow suppression, contraindicated with allopurinol
basilimixab
anti-CD25 receptor
etanercept
rhemetoid arthritis
glat. acetate
MS
imab
Crohn's disease
IFN beta
MS
IVIG
MS
nmab
last resort for MS
What four drugs for MS?
IFNbeta, nmab, IVIG, glat. acetate
2 Drugs that is invovled with IL-10 both used to treat MS
glat. acetate, IFN betaa
Drug used as last resort to treat MS, binds with alpha-4 integrin, preventing leukocyte migration into tissue
nmab
Only drug for Crohn’s disease
imab
2 drugs for TNF tumor necrosis factor
imab, etanercept
Which drug that binds to TNF treats rhemetoid arthritis?
etanercept
Which drug binds to CD11, involed with preventing leukocyte adhesion?
emab
which drug for psoriasis?
emab
How long after birth do you give anti-D(Rh antibody after birth to prevent susbesquent abortions?
72 hours
Anti CD25
bmab and dmab
ChronicGranDisease?
IFN gamma
Treat thrombocytopena
IL-11
cyclosporin
translplant, suppresses IL-2 transcription, binds cycolophillin
dmab
renal transplants, anti CD25, prevents binding of IL-2
emab
psoriasis, inhibits leukocyte migration binding to CD 11
muronab
anti CD3 wipes out T cells
mycophenolate mofeteil
selective lymphocyte proliferation inhibitor, by binding to inosine monophosphatte dehrogenase
prednisone
anti AP, binds to IFK preventing NFKbeta
sirolimus
upstream binds FKBP, inhibits calcineurin, inhibits NFAT, inhibits IL-2
tacrolimus
binds FKBP, inhibits calcineurin, inhibits NFAT, inhibits IL-2
IFN gamma
CGD