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140 Cards in this Set
- Front
- Back
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cell in germinal follicle
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B
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cell infected by EBV
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B
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HIV cell destroyed
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CD4TH
destorys type IV HSR |
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cell that destroys HBV hepatocytes
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CD8 Tcell
type IV |
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granuloma formation
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CD4 HTcell
macrophages via class II antigens type IV macrophages release IL1 - fever IL12 - Th cells --> Th1 memory cells |
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class I antigens on neoplastic cells, transplant, viral infections
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CD 8
type IV |
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CD3 molecule
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all T cells have CD3
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male dominant disease w absence of plasma cells and germinal follicles
failure of pre-B --> mature B |
Bruton's agammaglobulinemia
XR mutated tyrosine kinase |
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anaphylatic rxn when infused with blood products
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selective IgA immunodeficiency
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MC hereditary immunodeficiency syndrome
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selective igA
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gene therapy 1st
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SCIDS
AR disorder adenosine deaminase |
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failure of mature B --> plasma cells
no inheritance pattern |
common variable immunodeficiency
like bruton's sinopulmonary infections and giardiasis |
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SP disease, allergies, malabsorption, giardiasis
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selective IgA
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newborn with tetany and cyanotic congenital heart disease due to truncus arteriosus
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digeorge syndrome - 3rd and 4th pouches
hypoparathyroidism absent thymic shadow |
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ecxema
thrombocytopenia anergy malignant lymphomas |
Wiskott-Aldrich syndrome
XR tx'd with bone marrow transplant decreased IgM increased IgA and IgE |
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vessel abnormalitied, cerebellar disease, increased AFP, chromosome instability --> acute leukemias and lymphomas
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ataxia telangiectasia
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would pt with bruton's have intact cellular imunity?
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yes
ability to kill candida + skin reaction to candida |
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Bruton's have a defect in __
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opsonization
no IgG |
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digeore syndrome would have anergy to skin tests
T/F |
true
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DiGeorge syndrome potential for what??
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G vs H disease
pneumocystis jirovieci pneumonia |
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primary reservior cell for HIV in CNS is
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microglial
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HIV with fever, night sweats, cough, dyspnea, CD 350
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TB
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MC fungal infection in HIV
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candidiasis
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MC systemis fungus in CNS in AIDS
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cryptococcus
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AIDS -- watery diarrhea
oocysts that are acid fact |
cryptosporidiosis
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hairy leukoplakia,
AIDS defining? cause? |
EBV
not AIDS |
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AIDS
cotton wool exudates watery diarrhea biliary tract disease odynophagia |
CMV
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beefy red, painful perrectal ulcer -- gluteal folds
HIV |
herpes simplex
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early AIDS
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shingles
hairy leukoplakia- EBV oral candidiasis |
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Aids defining
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CMV
herpes esophagitis |
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inflammatory type of vasculitis- raised, painful erythematous leseions that blanch with pressure
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bacillary angiomatosis
bartonella henselae simulates kaposi's sarcoma |
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HIV + EBV =
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primary CNS lymphoma
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infiltrating squamous cell carcinoma in homosexual anorectal biopsy
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HPV proctitis
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HIV transmittion
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BLOOD
colostrum sweat does NOT carry virus viruses ARE in: tears urine saliva |
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asymptomatic latent clinical phase of HIV, virus is trapped in?
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lymph nodes by follicular dendritic cells
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HIV autoimmune disease
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thrombocytopenia
type II IgG antibody directed against GpIIb:IIIa fibrinogen receptor |
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hypergammaglobulinemia in AIDS is most often secondary to
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polyclonal stimulation of B cells by EBV
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inital screening test
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ELISA for gp-120 antibodies
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test to confirm
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western blot
requires the presence of antibodies against p24, pg 41 and either gp120 or gp160 |
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usually positive when pt first contracts HIV and when pt develops an aids defining lesion?
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p24 capture assay
detects p24 antigen and is positive when negative during early symptomatic phase |
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best overall info concerning the viral burden?
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HIV RNA by PCR
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AIDS-defining disease
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pneumocystis jiroveci pneumonia
systemic candidiasis kaposi's sarcoma invasive cervical cancer |
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needle stick triple therapy
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6 months
2 reverse transcriptase inhibitors + 1 protease inhibitor |
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fetus transmittion
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transplacental vertical transmission
second MC breat feeding |
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pregnant HIV
tx? baby will test __? |
+ ELISA test
tx: zidovudine (AZT) |
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AIDS have anergy to skin testing with candida?
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YES
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IgG levels are __ in AIDS
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increased due to EBV polyclonal stimulation
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space occupying lesion in CNS in AIDS MC
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toxoplasmosis
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MC initial AIDS- defining illness & tx
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pneumocystis
TMP/SMX |
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MCC recurrent pneumonia in AIDS
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Strep pneumo
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MCC fever, night sweats, weight loss in AIDS with CD4 <30
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disseminated MAI
mycobacterium avium-intracellular |
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AIDS complication directly due to HIV?
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dementia
wasting |
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recurrent pneumonias due to
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Strep pneumo
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primary CNS lymphoma due to
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EBV
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kaposi's sarcoma due to
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HHV 8
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progressive multifocal leukoencephalopathy due to
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papovavirus
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hairy leukoplakia due to
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EBV
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pg120 antigen attaches to _
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CD4 HTcell
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p24 antigen peaks _
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at two separate times during infection
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reverse transcriptase converts RNA to _
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dsDNA
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_ encodes for gp120/gp41
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env
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_ encodes for reverse transcriptase and integrase
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pol
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_ encodes for p24 antigen
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gag
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vaccines that CAN be given to AIDS
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killed polio
hep B MMR H. influ B Pneumovax Flu DTP |
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canNOT be given
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oral polio
varicella zoster |
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what is the ONLY live viral vaccine permitted to give to AIDS
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MMR
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anemia, thrombocytopenia, sternal tenderness to percussion, biventricular heart failure, hepatosplenomegaly, pitting edema with ascites, massive proteninuria, monoclonal spike in y-globulin region
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light chains
multiple myeloma with associated primary amyloidosis |
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40 yo w Alzheimer's, senile plaques in frontal lobe
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amyloid precursor protein --> b-amyloid protein
down syndrome chrom 21 senile plaques = pathognomonic of AD |
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chronic renal failure, hemodialysis, MI
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B2- microglobulin
hamodialysis-associated amyloidosis |
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HTN, hypercalcemia, thyroid cancer
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calcitonin
MEN IIb pheochromocytoma hyperPTH medullary carcinoma of thyroid (derive from c cells and produe calcitonin) calcitonin --> amyloid |
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RA CTS
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serum associated amyloid
RA --> deposition of SAA secondary amyloidosis in transverse carpal ligament |
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chronic heart failure hlow voltage ECG and arrhythmias refractory to tx
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transthyretin
senile cardia amyloidosis- typeo f restrictive cardiomyopathy secondary to mutant type of transthyretin |
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Armenian
recurrent attacks of fever and effusion of the jointslungs, and peritoneal cavity |
serum associated amyloid
familial mediterranean fever AR tx: colchicine |
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pancrease section of pt who dies of AMI
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islet cell amyloid
DM II |
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leprosy
macroglossia malabsorption proteinuria hepatosplenomegaly |
serum associated amyloid
SAA acute phase reactant classic secondary (reactive) amyloidosis are present |
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swelling of the face and larynx, inspiratory stidor
which C's are decreased? |
decreased C4 and C2 levels
C1 esterase inhibitor deficiency (hereditary angioedema) with no inhibitor of C1 esterase, C4 is activated --> C2 is activated C3 does NOT get activated |
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hereditary angioedema is A_?
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AD,
not recessive like most enxyme deficiences |
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what happens to factor B levels in here angio?
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normal levels since alternative pathway is NOT involved
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abdominal pain and hemoglobinuria in first AM void
sever normocytic anemia, thrombo, neuto |
paroxysmal nocturnal hemoglobinuria
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defect most likely responsivle for intravascular hymolysis is
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decay accelerating factor
DAF complement factors deposited on cell membrance cannot be degraded --> so cells are destroyed intravascularly |
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sugar water test and acidified serum test are for
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PNH
paroxysmal nocturnal hemoglobiniuria loss of DAF |
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HLA system is located on chromosome _ and is present on _
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chrom 6
on all nucleated cells AND platelets |
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loci A,B,C
loci D |
A, B, C = class I
D = class II |
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which transplant relationship is reversible
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acute only
use immunosuppression |
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ABO incompatible kidneys
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hyperacute rxn
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cyclosporine
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inhibits IL2 release
dose related renal tox |
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MC type of rejection
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acute
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decreased C3
normal C4 decreased factor B |
alternative pathway
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decreased C3
decreased C4 normal factor B |
classical pathway
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MC hereditary complement deficiency
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C2
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associated with disseminatied gonococcemia
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C6-C9
needed for phagocytosis MAC |
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most important initial test for transplantation
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ABO
hyperacute rejections |
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G vs H
most commonly seen in __ |
T cell deficiency
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most notorious transplants causeing G vs H disease
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BM & liver
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G vs H disease due to lymphocytes
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newborns and t cell deficient pts must have blood irradiated to kill lymphocytes
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pg120 antigen attaches to _
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CD4 HTcell
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p24 antigen peaks _
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at two separate times during infection
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reverse transcriptase converts RNA to _
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dsDNA
|
|
|
_ encodes for gp120/gp41
|
env
|
|
|
_ encodes for reverse transcriptase and integrase
|
pol
|
|
|
_ encodes for p24 antigen
|
gag
|
|
|
vaccines that CAN be given to AIDS
|
killed polio
hep B MMR H. influ B Pneumovax Flu DTP |
|
|
canNOT be given
|
oral polio
varicella zoster |
|
|
what is the ONLY live viral vaccine permitted to give to AIDS
|
MMR
|
|
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jaundice
skin rash diarrhea after BM transplant |
G vs H disease
|
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Ab mediated reaction (type II) --> vessel thrombosis and fibrosis
cell mediated rxn (type IV) --> attcks parenchymal cells with cytotoxic T cells |
acture renal rejection
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immediate host vessel thrombosis due to host Abs
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hyperacute rxn
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corneal trans
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best survival rates
danger of transiltting CJ prion |
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BM trans
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G vs H disease
disseminated CMV (live in lymphocytes) |
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MC primary malig related to immuno-suppresion
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squamous cell carcinoma of the skin
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CD4 TH2 cells are involved in type _ ?
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type I HSR
IgE |
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CD4 TH1 cells are involved in __ formation
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granulomas by TB
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IL4 secreted from
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CD4 TH1
IgM --> IgE stimulated CD4 and 8 cells stimulates B cells stimulates subset Th2 cells IgE syntheses |
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IL5
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B cell differentiation
production and activation of eosinophils |
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eczema
|
I
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hives
|
I
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drug skin rxn
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I
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hay fever
|
I
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poison ivy
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IV
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seasonal rhinitis
|
I
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bee stings
|
I
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anaphylactic rxn
|
I
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extrinsic asthma
|
I
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skin testig against mold
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I
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warm autoimmune hemolytic anemia
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II
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myasthenia gravis
|
II
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graves
|
II
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helminth killing
|
II
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post-strp GN
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III
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goodpastures
|
II
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rheumatic fever
|
II
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glomerulonephrits
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III
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serum sickness
|
III
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H-S purpura
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III
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RA
|
III
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contact derm to nickel
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IV
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TB
|
IV
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systemic fungal infections
|
IV
|
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PPD skin test
|
IV
|
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primary effector cell of type I
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mast cells and basophils
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