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35 Cards in this Set
- Front
- Back
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TLR
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found on innate immunity effector cells
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PAMPs
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recognized by TLRs
ex - endotoxin, peptidoglycan |
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HLA found on which chromosome?
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chromosome 6
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HLA class I
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found on all cells except RBCs
recognized by CD8 T cells, NK cells |
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HLA class II
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present on APCs
recognized by CD4 T cells |
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HLA-B27
dz? |
ankylosing spondylitis
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HLA-DR2
dz? |
multiple sclerosis
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HLA-DR3 and DR4
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T1DM
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CD16
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NK cells
role in antibody dependent cell-mediated cytotoxicity |
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which patient is at risk for blood transfusion reaction (correct ABO Rh matching)
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IgA deficient
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IgM present at birth may indicate
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congenital infection
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test for type 1 hypersensitivity
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scratch test
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test for type 2 hypersensitivity
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Direct and indirect Coomb's test
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test for type 3 hypersensitivity
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Immunofluorescent stain
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test for type 4 hypersensitivity
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Patch test
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contact dermatitis is what type HSR?
(ie, poison ivy, nickel) |
type IV
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hyperacute transplant rejection is what type HSR?
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type II
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acute transplant rejection with lymphocytic infiltrate, edema, endothelial injury is what type HSR?
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type IV
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SLE is what type of HSR?
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type III
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acute transplant rejection with vasculitis and intravascular thrombosis is what type HSR?
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type II
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serum sickness is what type of HSR?
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type III
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poststrep glomerlonephritis is what type of HSR?
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type III
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PPD is what type of HSR?
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type IV
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autoAb in SLE
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anti nuclear (ANA) - most sensitive
anti dsDNA Ab - more specific anti Smith - more specific |
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autoAb in drug-induced lupus
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anti histone Ab
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what type of transplant rejection is treatable with immunosuppression?
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acute rejection
NOT chronic |
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which drug is associated with drug induced lupus?
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procainamide, hydralazine
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malignancy risk in dermatomyositis and polymyositis?
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especially lung cancer
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AIDS defining infections
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PCP, systemic candidiasis
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AIDS defining malignancies
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Kaposi sarcoma (HHV8)
Burkitt lymphoma primary CNS lymphoma (EBV) |
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hereditary angioedema
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C1 esterase deficiency
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paroxysmal nocturnal hemoglobinuria
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decay accelerating factor (DAF) deficiency
protects self cells from complement |
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autoAb in CREST syndrome
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anticentromere Ab
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autoAb in Sjogren syndrome
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anti-SS-A
anti SS-B |
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autoAb in systemic scelorsis
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anti-topoisomerase
anti-nuclear (ANA) |
