Immunomodulators

Front 1

What is an alloimmune reaction when t planted cells attack recipient?

Back 1

Graft vs. Host Dx

Front 2

What type of solid organ rejection do you have with preformed Ab reacting with donor Ag and activating compement?

Back 2

Hyperacute

Front 3

How would you suppress Hyperacute Solid Organ Rejection?

Back 3

suppressed by matching donor and recipient blood types

Front 4

What type of solid organ rejection has the mechanism of donor Ag activating recipeint T cells or recipeient generates Ab to donor ag?

Back 4

Acute

Front 5

How would you suppress Acute solid organ rejections?

Back 5

immunosuppression

Front 6

What cytokin inhibitor is used alternatively to methotrexate for RA tx?

Back 6

Cyclosporin

Front 7

What drug diffuses into cell and bind cyclophilin to make calcineurin?

Back 7

Cyclosporin

Front 8

What cytokine inhibitor is extensively metabolied by cytochorome P450?

Back 8

cyclosporin

Front 9

Cyclosporins are used for what reason?

Back 9

to prevent kidney, liver and cardiac transplants

Front 10

What is the most important adverse effect to consider with cyclosporin?

Back 10

nephrotoxicity

Front 11

What drug is preferred over cyclosporins b/c it has increased potency, dec rejection, and lower dose of corticosteroids?

Back 11

Tacrolimus

Front 12

What drug is post transpant insulin dep. diabetes a concern?

Back 12

Tacrolimus

Front 13

What drug is used in renal patients and is given with cyclsporine and corticosteroids?

Back 13

Sirolimus

Front 14

What bind FK binding ptn which inhibitsmTOR thereby inhibiting translation f genes that allow cell to transition from G1 to S phase?

Back 14

Sirolimus

Front 15

What drug has side effects such as hyperlipidemia, leucopenia, and throbocytopenia?

Back 15

Sirolimu

Front 16

What is used in CVD and prevents smooth muscle proliferation nd restenosis?

Back 16

Sirolimus

Front 17

What blocks IL1 and thus prevents pain and swelling?

Back 17

Anakinra

Front 18

What slows dev. of bony erosions in RA pts?

Back 18

Aakinra

Front 19

What type of drugs compete and inhibit essential parts of metabolism?

Back 19

Antimetabolites

Front 20

What drug suppresses tplant rejection and inflammatory bowel dx?

Back 20

Azathioprine

Front 21

What drug has the mechanism of converting 6-MP in the body then to thioninosini acid which is a nucleotide analog?

Back 21

Azathioprine

Front 22

What drug is used to tx RA, psoriass, and GVHD?

Back 22

Methotrexate

Front 23

What drug incerases adenosine levels and is thus a potent anti-inflamatory drug?

Back 23

Methotrexate

Front 24

What drug inhibits inosine monoP dehydrogenase I?

Back 24

Mycophenolid Acid- MMF

Front 25

How is myophenolic acid adminisitered?

Back 25

as myophenolate

Front 26

What drug is used in adult renal tplants and has delay GI absorption and dec adverse GI effects compared to MMF?

Back 26

Mycophenolate Sodium

Front 27

What drug inhibits pyrimidine synthesis by blocking essential dehydrogenase enzymes?

Back 27

Leflunomide

Front 28

What drug is used to treat RA but has adverse effects of diarrhea and alopecia?

Back 28

Leflunomide

Front 29

What drug is used to treat cancer and humoral diseases by alkylating DNA?

Back 29

Cyclophosphamide

Front 30

What are the components of Cytotxic Drug Agents? (the 2 subgroups)

Back 30

Antimetabolites and Alkylating Agents

Front 31

List the Antimetabolites.

Back 31

Azathioprine
Methotrexate
Mycophenolic Acid MMF
Mycophenolate Sodium
Leflucnomide

Front 32

What is a polyclonal Ab that can target many T cells ad leads to broad immunosuppression that can lead to infxn?

Back 32

Antithymocyte Globulin

Front 33

What is Antithymocyte Globulin used to treat?

Back 33

Acute Renal Transplant Rejection

Front 34

What is an adverse effect of using Antithymocyte Globulin?

Back 34

Cytokine Release Syndrome

Front 35

What is fever, HA,myalgia and nausea that is caused y initial activation of T cells and releae of cytokines before T cell clearance by MO called?

Back 35

Cytokine Release Syndrome

Front 36

What is a monoclonal Ab against CD3 and thereby decrease T cells?

Back 36

Muromonab CD3- result in proound but transient immunosuppression

Front 37

What is the mechanism of Anti-DC25 MAB?

Back 37

blocks IL-2 receptor

Front 38

What are two drugs that block IL-2 receptors?

Back 38

Daclizumab
Basiliximab

Front 39

What is a drug that blocks IL-2 receptors and is administered prophylactically with renal transplants?

Back 39

Anti-CD25 MAB

Front 40

What is used to treat RA by keeping a sustained depletion of T cells?

Back 40

Anti-CD52 MAB

Front 41

What is a drug that is used to treat chroni B cell leukemia by sustaining depletion of T cells?

Back 41

Alemtuzumab

Front 42

What is used to treat RA and Crohns dx by blocking TNF and leading to a decreased in inflammtory cytokines Il-1 and IL-6?

Back 42

TNFalpha Inhibitors

Front 43

What is an adverse effect of TNfalpha Inhibitors?

Back 43

Inc risk of Lymphoma

Front 44

What are3 drugs that are TNFalpha Inhibitors?

Back 44

Etanercepts
Infliximab
Adalimumab

Front 45

What is a steroid hormone that binds cytosolic glucocorticoid receptor and downregulates TNF alpha, IL-1 and IL-4 as well as inhibitsing phospholipase A2?

Back 45

Glucoorticoids

Front 46

What glucocorticoid would you use for transplants?

Back 46

Prednisone and Methylprednisone

Front 47

What glucocorticoid would you use for autoimmunity?

Back 47

Prednisone and Predinisolone

Front 48

What immunomodulator inhibits IL-2 synthesis?

Back 48

Cyclosporins and Tacrolimus

Front 49

What immunomodulator inhibits response to IL-2?

Back 49

Sirolimus