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36 Cards in this Set
- Front
- Back
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Histamine
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Vasodilate, Increase mucus
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Prostiglandins
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Vasodilate, increase permeability
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Leukotrienes
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Increase mucus, Bronchoconstrict
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Chemokines
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Attract cells to site
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Platelet activating factor
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Chemotaxis, activate PMN (granulocytes)
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Enzymatic mediators
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Cell movement, damage and repair of tissue
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C3a, C4a
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↑Vaso dilation, ↑permiability, Anaphylatoxin, phagocyte recruitment
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C5a
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↑Vaso dilation, ↑permiability, Anaphylatoxin, Chemotactic factor, phagocyte recruitment
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Erythropoietin
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Erythrocytes
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TNF
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Triggers apoptosis,↑CAM, ↑fever, ↑cytokines
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IL-1 (Interleukin 1)
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Fever, Activate Endothelium (attract neutrophils)
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IL-2
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T-cell growth, T & B proliferation, NK prolif.
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IL-3
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Growth of early hematopoietic progenitor cells
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IL-4 Made by TH2
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B-cell proliferation; IgE production
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IL-5 Made by TH2 and mast
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B cell growth, AB secretion, eosinophil activation, Isotype switch to IgA
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IL-6
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Fever, acute phase response
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IL-8
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Chemotaxis (recruit neutrophils)
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IL-10 made by mф and TH2
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Inhibits macrophage and dendritic cells
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IL-12 Made by mф and dendrites
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Differentiation of t-cells, ↑ NK toxins, anti-angiogenic, Stim INF-γ, TH1 production
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IL-17
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Induces inflammatory cytokines and PMN, Recruitment
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INF-α Type I
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Antiviral
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INF-β Type I
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Antiviral
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INF-γ Type II
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Macrophage and NK activation, IgG, B and MHC production
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G-CSF
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Stimulates granulocyte and stem cells
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M-CSF
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Stimulates monocytes and macrophages
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GM-CSF
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Stimulates granulocytes and monocytes
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TGF-β
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Inhibitory of macrophage T/B; anti-inflammatory, IgA
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CD3
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T-cells, Thymocytes à Signal Tranduction by the TCR
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CD4
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T-cell, monocyte, macrophage à Signaling and adhesion co-receptor (binds Class II MHC)
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CD8
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T-cell subset, thymocytes à Signaling and adhesion bind to Class I MHC
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CD28
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T- cell à Binds B7-1 (CD80) and B7-2 (CD86) as co-stimulator
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CD40
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B cells, Macs, DC, endo à Binds CD40L (CD154) on T cells to provide T-cell help ; Mac activation
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CD80
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Synonym --> B7-1
On APC binds to CD28 turns T-cell on |
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CD86
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Synonym --> B7-2
On APC binds to CD28 turns T-cell on |
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CD152
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Synonym --> CTLA-4
On APC binds to CD28 turns T-cell OFF |
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CD154
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Synonym --> CD40 ligand
On T- cell Binds to B-cell CD40 |
