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15 Cards in this Set

  • Front
  • Back
plasma
fluid left after blood cells removed; can clot
serum
fluid left after blood cells and blood clotting removed
one of primary mechs by which pathogen recognition converted to effective host defense --> immediate
complement
3 mechs of complement
1)MAC (c5b to C9); lysis
2)opsonization; (c3b)
3)inflammatory/anaphylatoxins (c3a c5a)
complement in plasma
inactive in plasma; once activated, cascade amplification of inflammation
C3B actions
1)opsonization
2)c5 convertase
complement early events
3 paths to c3 convertase
complement late events
MAC formation, effect of proteolytic components (c3b, c3a, c4a, c5a)
effect of proteolytic components (c3b, c3a, c4a, c5a)
1)c3a, c4a, c5a stimulate histamine release
2)c5a - lipoxygenase pathway in neutrophils and monocytes
c5a chemoattracts N,M,E,B leukocytes
4)c3b and ic3b - opsonize
deficiency of c1 inhibition (c1INH)
episodic edema;accumulation in skin, extremities, intestinal mucosa, laryngeal mucosa
deficiency of C2 and C4(fail to activate complement)
autoimmune, such as SLE; antigen-antibody complexes not cleared
deficiency of MAC
more susceptible only to Neisseria
inhibition of C1
c1INH - binds c1, interferes with enzyme activity.
Key complement inhibitory point
C3 and C5 regularion.
DAF (increased decay rate)and factor I(cleaves c3b)
inhibition of MAC
CD59 and several others