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15 Cards in this Set
- Front
- Back
plasma
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fluid left after blood cells removed; can clot
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serum
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fluid left after blood cells and blood clotting removed
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one of primary mechs by which pathogen recognition converted to effective host defense --> immediate
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complement
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3 mechs of complement
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1)MAC (c5b to C9); lysis
2)opsonization; (c3b) 3)inflammatory/anaphylatoxins (c3a c5a) |
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complement in plasma
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inactive in plasma; once activated, cascade amplification of inflammation
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C3B actions
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1)opsonization
2)c5 convertase |
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complement early events
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3 paths to c3 convertase
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complement late events
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MAC formation, effect of proteolytic components (c3b, c3a, c4a, c5a)
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effect of proteolytic components (c3b, c3a, c4a, c5a)
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1)c3a, c4a, c5a stimulate histamine release
2)c5a - lipoxygenase pathway in neutrophils and monocytes c5a chemoattracts N,M,E,B leukocytes 4)c3b and ic3b - opsonize |
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deficiency of c1 inhibition (c1INH)
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episodic edema;accumulation in skin, extremities, intestinal mucosa, laryngeal mucosa
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deficiency of C2 and C4(fail to activate complement)
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autoimmune, such as SLE; antigen-antibody complexes not cleared
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deficiency of MAC
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more susceptible only to Neisseria
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inhibition of C1
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c1INH - binds c1, interferes with enzyme activity.
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Key complement inhibitory point
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C3 and C5 regularion.
DAF (increased decay rate)and factor I(cleaves c3b) |
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inhibition of MAC
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CD59 and several others
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