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15 Cards in this Set

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isograft
graft between genetically identical subjects
-these are accepted graft transplants
allograft
graft between same species but different genotype
-these are rejected transplants
xenograft
graft between subjects from different species
autochthonous tissue
tissue from same individual
chimera
an individual organism whose body contains cell populations derived from different zygotes, of the same or different species.
-host may not develop an immune response to this
self-recognition
-differentiation of self substances from foreign substances
-can be proteins, carbohydrates, etc.
-clonal deletion mechanism
-sponge species example
immune specificity
-T-cells and B-cells have a predisposed specificity to respond to a particular epitope or antigenic receptor
-each inidvidual cell can respond to only one epitope
-as a population can recognize ~1 billion DIFFERENT epitopes
Antigen
-a substance to which the immune system can react
-usually foreign (non-self)
immune repertoire
the ability of the immune system to respond to perhaps 1 billion antigenic determinants
immune response
-antibody AND cell-mediated reactions to antigen
-involves B-lymphocytes, T-lymphocytes and APCs
non-specific/innate immunity
-based on the genetic constitution of the individual
-non-specific means of clearing or removing most undesirable substances
specific/adaptive immunity
-acquired immunity
-specific immunity attributable to the presence of antibody or reactive lymphocytes following prior exposure to an infectious agent or antigenic substance
complement
complex biological system that covalently binds specific proteins to the microbial surface that can destroy invading microorganisms
classical complement pathway
triggered when antibodies bind to an organism
-initial component is C1
-activated by IgG -requires 2(less active) and IgM (more active)
MHC
a gene complex that codes specialized receptor glycoproteins
-determines which antigens are processed and presented
-control antigen processing and presentation