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25 Cards in this Set
- Front
- Back
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What is the general consequence of type III HS?
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activation of comlplenent and inflammation leading to tissue damage
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Why do intermediate or small complexes bind less avidly to pahgocytic cells?
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circulate for a longer a longer period of time
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WHat are the favored sites for depostioin of immune complexes?
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kidneys
joints heart small vessells skin |
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WHat is the general mechanism of type III HS reactions?
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complenment and Fc receptor mediated recruitment and activation of inflammatory cells
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What is the progressin of Immnue complex depostion in vessels that lead to microthrombus formation?
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Immune complex deposition
then platelet aggregation then microthrombus formation |
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When does the zone of equivalence occur in type III HS?
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8-13 days post initial Ag load
causes serum sickness |
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WHat happens when small drug molecules (penicillin) serve as haptens that bind to serum proteins?
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get Ab response, either to the Hapten or the hapten-protein conjugate
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What Ig is produced abnormally, which has specificity for the determinats on the Fc portion of the patients' own IgG, in rheumatiod Arthritis?
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IgM
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What is an alternate name given to the IgM produced in Rheumatoid Athritis?
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Rheumatoid factor and it is depositied in joints
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When does serum sickness usually occur?
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upon second exposure to the offending Ag
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What is a well known disease in which DS DNA and other nucleoproteins are acttacked by complement and Fc receptor inflammation?
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SLE
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What are the clinical manifestaon of SLE?
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nephritis, arhtritis, and vasculatis
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Which componenents of the classical complement pathway are mosly involved in SLE?
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C2 and C4
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What is the genetic deficicy associated with SLE?
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associated with HLA DR3 and DR2/and or deficiencies of C2 and C4
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Which type III HS is associated with hep B viral surface Ag being attacked via comlement and Fc receptor mediated inflammation, and causes a vasculaitis?
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Polyarteritis Nodosa
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What cells compose the vascular infiltrates in poly arteritis nodosa?
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neutrophils, macrophages, and lymphocytes
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What doe complement and Fc receptor-mediated inflammation attack in the setting of post-strp glomerulonephritis?
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streptoccal cell wall Ags
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What strep group is associated with post strep glomerulonephritis?
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strep A
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Why does the Arthus reaction happen?
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Ag is injected in to the dermis if the patient and encouters and previously produced AB to that Ag, this immune complexwill activate complement
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What happens upon complenet activation in the arthus reaction?
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neutro degranulation, neutrophil chemotaxis and mast cell degranulation, platelet aggregation with in the vessel (release of vasoactive amines
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How long doe the Arthus reaction take to develop?
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~12 hours
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WHat is the most common cause an occupational intrapulmonary arthus type rxn, in which sensitive individuals produce IgG against moldy hay?
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Farmars Lung
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What is a test for detecting Type III reactions?
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direct immunofluorescent staining with anti-Ig Ab
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What pattern does immunofluorescent staining exhibit when testing for type III HS rxns?
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'lumpy-bumpy' irregular pattern
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What technique is used to measure complement levelas (C3 and C4) in an indirect measurement?
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nephelometry
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