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12 Cards in this Set
- Front
- Back
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What aspect of the immune system mediates the response to graft rejections?
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T cells
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What is the difference between an Autologous and Allogenic transplant?
What is Syngeneic? |
Autologous – same individual is both donor and recipient
Allogeneic - from different individual/ same species Syngeneic - from identical individual/ same species |
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What are the transplantation "antigens"?
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MHCs
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* What are the two allogenic responses in transplants?
is this a strong reaction? |
1. Allo-MHC looks like self-MHC bearing foreign peptide
2. both Allo-MHC and peptide recognized as foreign VERY; can cause cross-reactions |
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What are the three classes of graft rejection?
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1. hyperacute (minutes)
2. acute (days or weeks) 3. chronic (months or years) |
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What causes a hyperacute graft rejection?
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B cells: memory response from prior exposure
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* What is the end result of chronic graft rejection?
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Fibrosis, arteriosclerosis, gradual loss of grafted tissue
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What mediates an acute graft rejection? hyperacute?
what are being produced in chronic rejection? |
T cells (recall: days to weeks)
B cells (memory) Cytokines --> vessel occlusion |
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* What is a common treatment for graft rejection? what is the "target" in many therapies?
prevention? |
Immunosuppression (T cells) --> IL-2 (activation and proliferation pathway)
Prevention = MHC matching |
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* What is the "original" transplant and what aspect of the immune system is involved?
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blood and marrow transfusions
B cells (ABO) |
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What is a newer, less invasive method of collecting bone marrow (stem cells)?
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Mobilization of stem cells to periphery --> collection in blood --> leukopheresis
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Does the donor tissue need to be prepared in any way? why?
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YES! T cell depletion --> prevent Graft v. Host attack
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