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35 Cards in this Set

  • Front
  • Back
Before a mature naïve Bcell must ? – before they have made contact w/ its sp. An?
1) Periodically pause in a primary follicle in order to survive and continue its recirculation
within the follicle the mature naïve Bcell ?
1) receives survival signals
a) may come from follicular dendritic cells
how many B cells leave the bone Marrow daily?
1) 30 billion > circulating naïve B cells
what does the B cells pause in the follicular sites cause?
1) Continual competition b/t circ naïve B cells passage thru limited # of follicular sites
a) The majority of mature, naïve B cells die after only a few days in peripheral circulation.
Mature Naive B cells compete?
for access to lymphoid follicles.
After maturing in the bone marrow where to B cells migrate to?
1) In the blood to lymph nodes and other 2nd tissues
how do B cells enter the lymph node?
1) leave the blood and enter the cortex
a) thru the walls of HEV
1) Specialized high endothelial venules
If B cells do not encounter their specific antigen?
1) It passes thru the prim follicles and leave the node
a) Thru efferent lymph>blood.
B cells encounter with An, leads to?
1) Differentiation of activated Bcells into
a) Plasma cells
b) Memory B cells
plasma cells?
1) secrete antibody
Antibody secretion is effected by?
1) a change in the processing of the H-chain mRNA
a) Leads to the synthesis of secreted form of Ig rather than memrane bound form
Activated B cell?
1) Migrates > 2nd lymphoid follicle (aka germ center
a) To become centroblasts
(i) Which mature into centrocytes
secondary lymphoid follicle?
1) contains germinal center
2) activated B cells b/c centroblasts here
1) Large proliferating lymphoblasts
a) Mature into centrocytes
1) non-dividing B cells
2) which have undergone isotype switching and somatic hypermutation
Germinal center B cells develop into?
1) Memory B cells
Memory B cells?
1) Posess high-affinity, isotype-switched antigen receptors
production of mem cells after successful antigen encounter establishes?
1) Antigen specificities of proven usefulness permanently in the B cell repertoire
what are some properties of mem B cells?
1) Persist for long periods of time
2) During recirculation require only intermittent stim. From follicular env.
3) More easily activated on An encounter than vaive B cells
4) Secondary immune response
Secondary immune response?
1) Due to rapid active, and differentiation ointo plasma cells on subsequent encounter w/ An.
2) Develops more quickly than prim
3) Stronger than prim.
B cells encountering An in 2nd lymph tiss. Form and undergo?
1) Germinal centers
2) Differentiation into plasma cells
a B cell enters the lymph node and encounters An where?
1) In the lymph node cortex
what is the B cell activated by?
1) CD4 helper T cells
a) In T cell area
encounter with CD4 T cells form? Go where?
1) primary focus of dividing cells
a) medullary cords
b) primary follicle
B cells that migrate directly to the medullary cord?
1) Differentiate into Ab secreting plasma cells
cells that migrate to the primary follicle?
1) Form germinal centers
a) Where the continure to divide and differentiate
activated B cells?
1) Migrate from the germinal center to
a) the medulla of lymph node
b) bone marrow
(i) to complete diff. into plasma cells
Different types of B cell tumors?
reflect B cells at diff. stages of development
B cell rumore arise from?
both B1 and B2 lineages
and at diff stages of maturation and differentiation.
in a b cell tumor - every cell?
1) Has identical Ig-gene rearrangement
a) = proof of their derivation from same cell.
1) Retain characteristics of the cell type from which they arose
follicular center cell lymphoma?
1) tumors derived from mature, naïve B cells
a) grow in the follicles of lymph nodes
1) plasma-cell tumors
a) propagate in bone marrow
Hodkin’s disease?
1) One of the 1st tumors to b successfully treated by radiotatapy
2) Origin = germinal center B cell
3) Result = somatic mutation
a) No longer have An receptor.