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26 Cards in this Set

  • Front
  • Back
The distinction between variolation and vaccination?
In vaccination a nonviable antigen is injected
Characteristics of innate immunity
constitutive, rapid, nonspecific, and lack of memory
What can the innate immune system not recognize?
nonmicrobial molecules
5 External defenses of the innate immune system?
1. intact skin
2. tears
3. in the respiratory tract
4. in the digestive tract
5. normal intestinal flora
5 Internal defenses of the innate immune system?
1. chemical/physio barriers
2. NK cells
3. interferons and cytokines
4. alternative complement pathway
5. detetion of pathogens
What is an example of a PAMP on gram-negative bacteria?
Why do T-cells need 2 signals?
To distinguish self from non-self
How do phagocytes degrade ingested material?
Fusing with a lysosome to form a phagolysosome
What cells can mediate phagocytosis?
Monocytes/Macrophages, Dendritic Cells, and Neutrophils
How do B and T cells interact with antigens?
2 types of memory cells
Effector and Central
Cell/mediated immunity provides protection against viruses in what phase?
Where do antigens and B-cells interact?
spleen and lymph nodes
2 pathways of hematopoietic stem cells and their products?
Lymphoid- B and T cells
Myeloid- erthrocytes, megakaryocytes, basophils, eosinophils, neutrophils, monocytes, and DCs
What are the only cells in the body responsible for humoral immunity?
B cells
What on B-cells recognizes native antigen?
What do mature B-cells express?
IgM and IgD
What is the pathway of immature T-cells in terms of CD4CD8?
double negative, the double positive, then single positive
Where are circulating DCs found?
in the blood and lymph
Where are Interdigitating DCs found?
T-cell areas of secondary lymphoid tissue and the thymic medulla
Where are Interstitial DCs found?
most organs
Where are Langerhans cells found?
in the epidermis and mucous membranes
What are iccosomes?
structures on follicular DCs that are covered in antibody-antigen complexes
NK cells use Antibody-Dependent Cell-Mediated Cytotoxicity to kill what targets?
Targets coated in IgG antibody
What type of lymphatics do the bone marrow, spleen and thymus have?
Only efferent lymphatics
What do stem cells become when they become metabolically active?
progenitor cells