Immunology Pharm

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Cyclosporine

Back 1

Class: Immuno-suppressant
MOA: Binds to cyclophilins, C:C complex inhibits calcineurin thus preventing IL-2 production and thus blocking the differentiation and activation of T cells
Clinical use: suppress organ rejection post transplant & Selective autoimmune disorders
Adverse Effects: Predisposes to viral infections and lymphoma, Nephrotoxic (prevent with mannitol diuresis)

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Tacrolimus (FK506)

Back 2

Class: Immuno-suppression
MOA: binds FK-binding protein inhibiting IL-2 secretion and other cytokines
Clinical use: Immunosuppresant used in organ transplant (very potent)
Adverse Effects: Significant-Nephrotoxicity, peripheral neuropathy, HTN, pleural effusion, hyperglycemia

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Azathioprine

Back 3

Class: immuno-suppresant
MOA: Antimetabolite precursor of 6-MP that interferes with nucleic acid metabolism\synthesis
Toxic to proliferating lymphocytes
Clinical use: Kidney transplants, Autoimmune Disease (glomerulonephritis and hemolytic anemia)
Adverse Effect: Bone Marrow Suppression
Interactions: Active Metabolite (6-Mercapto-purine) is metabolized by xanthine oxidase (so do NOT use allopurinol with this)

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Muromonab-CD3 (OKT3)

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Class: Immunosuppresant
MOA: Anti CD3 antibody (epsilon chain). Blocks cellular interaction CD3 so T cell transduction cannot occur.
Clinical use: Immunosuppresant and Kidney Transplant
Adverse Effects: "Cytokine Release Syndrome" , Hypersensitivity reaction

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Sirolimus (rapamycin)

Back 5

Class: Immunosuppresant
MOA: Binds to mTOR (mammalian target of rapamycin) and inhibits T-cell proliferation in response to IL-2 (blocks protein translation)
Clinical use:Kidney transplant immunosuppresion in combination with cyclosporine and CST’s, In drug eluting stents, Lung cancer therapy (downstream from PI3k\AKT pathway
Adverse Effects: Hyperlipidemia, thrombocytopenia, leukopenia

Front 6

mycophenolate mofetil

Back 6

Class: Immunosuppression
MOA:Inhibits de novo guanine synthesis and blocks lymphocyte production

Front 7

Daclizumab

Back 7

Class: Immunosuppression
MOA: Monoclonal antibody with high affinity for the IL-2 receptor on activated T-cells

Front 8

Aldesleukin

Back 8

Class: Recombinant cytokine
MOA: IL-2
Clinical Use: RCC, Metastatic Myeloma

Front 9

Erythropoitin

Back 9

Class: Recombinant cytokine
MOA: EPO
Clinical use: Anemias (especially in renal failure), Cancer chemotherapy

Front 10

Filgastrim

Back 10

Class: Recombinant cytokine
MOA: G-CSF
Clinical use: Bone marrow post chemotherapy

Front 11

Sargramostim

Back 11

Class: Recombinant cytokine
MOA: GM-CSF
Clinical use: Bone marrow recovery post chemotherapy

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IFN-alpha

Back 12

Class: Recombinant cytokine
MOA: IFN-alpha
Clinical use: HBV, HCV, kaposi, Melanoma, Leukemia

Front 13

IFN-Beta

Back 13

Class: Recombinant cytokine
MOA: IFN-Beta
Clinical use: MS

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IFN-gamma

Back 14

Class: Recombinant cytokine
MOA: IFN-gamma
Clinical use: Chronic granulomatous disease

Front 15

Oprelvekin

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Class: Recombinant cytokine
MOA: IL-11
Clinical use: Thrombocytopenia

Front 16

Thrombopoitin

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Class: Recombinant cytokine
MOA: TPO
Clinical use: Thrombocytopenia