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25 Cards in this Set
- Front
- Back
Tumor necrosis factor (TNF). |
Source: Macrophages, T cells. Principal targets and biological effects: -Endothelial cells: Activation. (Inflammation + coagulation) -Neutrophils: Activation. -Hypothalamus: Fever. -Liver: Synthesis of acute-phase proteins. -Muscle/fat: Catabolism (cachexia). |
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Interleukin-1 (IL-1). |
Source: Macrophages, endothelial cells, some epithelial cells. Principal targets and biological effects: -Endothelial cells: Activation (Inflammation + coagulation) -Hypothalamus: Fever -Liver:Synthesis of acute-phase proteins -T cells: Th17 differentiation |
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Chemokines. |
Source: Macrophages, DC, endothelial cells, T cells, fibroblasts, platelets. Principal targets and biological effects: -Leukocytes: Increased intergin affinity, chemotaxis, activation. |
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Interleukin-12 (IL-12). |
Source: DC, MØ Principal targets and biological effects: -NK & T cells: IFN-y production, increased cytotoxic activity -T cells: Th1 differentiation |
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Interferon-y (IFN-y). |
Source: NK cells, T lymphocytes Principal targets and biological effects: -Macrophages: Activation -Stimulation of some antibody responses |
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Type I IFNs. (IFN-@, IFN-b) |
Source: DC, macrophages (IFN-@), fibroblasts (IFN-b) Principal targets and biological effects: -All cells: antiviral state, increased class I MHC expression -NK cells: activation |
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Interleukin-10 (IL-10). |
Source: MØ, DC, T cells Principal targets and biological effects: -MØ, DC: inhibition of IL-12 production, decreased expression of costimulators & class II MHC molecules |
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Interleukin-6 (IL-6). |
Source: MØ, endothelial cells, T cells Principal targets and biological effects: -Liver: Synthesis of acute-phase proteins -B cells: Proliferation of antibody-producing cells |
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Interleukin-15 (IL-15). |
Source: MØ, others Principal targets and biological effects: -NK cells: Proliferation -T cells: Proliferation |
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Interleukin-18 (IL-18). |
Source: MØ Principal targets and biological effects: -NK cells & T cells: IFN-y synthesis |
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TGF-B. |
Source: Many cell types Principal targets and biological effects: -Inhibition of inflammation -T cells: differentiation of Th17, regulatory T cells |
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T cell maturation deficiency (2): |
- SCID common y chain deficiency - DiGeorge syndrome |
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Immunoglobulin class switch deficiency (1): |
- Hyper IgM syndrome |
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Antigen presentation deficiency (1): |
- Bare lymphocyte syndrome (BLS). |
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Regulation of leukocyte migration deficiency (3): |
- Wiskott-Aldrich syndrome - Leukocyte adhesion deficiency (LAD) - WHIM syndrome |
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Regulation of phagocytosis deficiency (2): |
- Chronic Granulomatosus Disease (CGD) - Chediak-Higashi syndrome |
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Regulation of immune responses deficiency (1): |
- IPEX syndrome |
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Regulation of apoptosis deficiency (1): |
- Autoimmune Lymphoproliferative Syndrome (ALPS) |
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DNA repair deficiency (2): |
- Ataxia teleangiectasia - Nijmegen breakage syndrome |
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T-B-NK- |
- ADA deficiency - PNP deficiency |
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T-B-NK+ |
- RAG1 &/or RAG2 deficiency - Omenn syndrome (mutation in RAG1/RAG2) - SCID Atabasca or Navajo (mutation in gene Artemis) |
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T-B+NK- |
- Mutation in y chain (gene IL2RG) - x-linked mutation in JAK3 |
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T-B+NK+ |
- Mutation in IL-7R@ |
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T-B+ |
- CD45 deficiency - CD3 deficiency |
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T+B+ |
- ZAP-70 deficiency - IL-2 deficiency - CD25 deficiency |