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20 Cards in this Set
- Front
- Back
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what are the terminal cells in the B cell line
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plasma cells
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difference between B and T cell receptors
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TCR are always membrane boudn and never secreted
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functions of humoral response
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protection against microbes or foregin particles
destruction (as in anaphylaxis) |
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what %age of lymphocytes are T cells
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55-75
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some chars of the B and T memory cells
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(i) These cells are small lymphocytes (ii) They are metabolically inactive (iii) They are recirculated from blood--to—lymph--to--blood (iv) They have a very long half-life(months to years)
(v) They can turn on very rapidly in presence of Ag-this is the basis of booster shots. This also explains why we have a life long resistance to certain Ag. If this antigen is seen a second time, the memory cells respond initially to this Ag very rapidly but no disease is seen. (vi) They are precursors of T helper and plasma cells. |
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How is the switch from IgM (primary Ab response) to IgG (secondary Ab response) made?
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This "class switch" occurs in plasma cells. The Mu (u) variable gene segment is spliced out and is replaced by a variable segment of gamma 1, 2, 3, or 4 (γ’, γ2, γ3, γ4). The light chain and the VH, D, and J segments of the heavy chain stay intact. We have now created a new molecule with the same Ag specificity but have a different heavy chain constant region segment. Note: the type of heavy chain gene selected is under the influence of cytokines produced by T-cells.
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what is important about the function of IL-4
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it induces the IgE switch which we will see is VERY importnat in allergic disease
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PRIMARY VS SECONDARY
latent period |
long vs. short
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PRIMARY VS SECONDARY
rate of antibody synthesis |
low vs. high
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PRIMARY VS SECONDARY
peak antibody titer |
low vs. high
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PRIMARY VS SECONDARY
persistence of antibody titer |
short vs long
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PRIMARY VS SECONDARY
affinity of antibody |
low vs high
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PRIMARY VS SECONDARY
gross-reactivity of antibody |
low vs high
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PRIMARY VS SECONDARY
presence of memory cells |
few vs many
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PRIMARY VS SECONDARY
predominating ig class |
M vs G
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PRIMARY VS SECONDARY
dose of immunogen to elicit |
high vs low
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what are the factors that influence the quantity and quality of antibody formation
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1 - route of administration (if you breath it in - IgA if you inject it into iv - IgG)
2 - dose of immunogen - too high no reponse 3 - type of immunogen - some are good some are bad |
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Constitute 2-12 % of cells
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Macrophages:
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T-Cell
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Constitute 55%-75% of lymphocytes in the peripheral blood of which of which 70% of these are memory cells
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B-Cell
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Constitute 15%-30% of the lymphocytes in the circulating blood of which 25% of these are memory cells
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