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8 Cards in this Set
- Front
- Back
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What type of immunity can be invoked in response to tumors
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Both Cell-mediated and Humoral immunity
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What are tumor-associated transplantation antigens (TATAs)
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Antigens normally expressed only at certain stages of differentiation or only by certain lineages of cells
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What are tumor-specific transplantation antigens of chemically induced tumors
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Each tumor from a given chemical compound will express different antigens in the same host cell type
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What are tumor-specific transplantation antigens associated with viruses
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Each tumor from a given virus will express the same antigens, regardless of host cell type.
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What are some viruses implicated in tumors
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Epstein-Barr virus (Burkitt's lymphoma); Human papilloma virus (HPV); Hepatitis B and C viruses
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What are the adaptive immune responses against tumors
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1. Antibody mediated. Anti-tumor antibodies and complement; B cells recognize tumor antigens and secrete Ig
2. T cell mediated. Recognize tumor antigens with MHC 1; CD4 cells activate cytokine production |
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How do tumors actively evade the immune system
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Sneaking through (few antigenic determinants masks their numbers); Tumor treated as self; Antigenic modulation; Down regulation of MHC class 1
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How do tumor cells passively evade the immune system
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Immunodeficiency of the host; Immunosuppresion (both Iatrogenic and tumor-induced); Enhancing (blocking) antibodies
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