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15 Cards in this Set
- Front
- Back
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Describe the structure of an antibody
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Heavy and light chains, variable and constant regions, fc fragment,
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What is the difference between a BCR and an antibody? (Both are immunoglobulins)
What are the structural differenes? |
BCRs are attached to the cell surface of a B cell while antibodies are secreted by the B cell
Structure |
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What types of antigens can be recognized by an immunoglobulin?
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Proteins, carbohydrates, ?lipids? ?other small molecules?
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What form of epitope do immunoglobulins recognize?
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Both linear and discontinuous
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What is the difference between an epitope and an antigen?
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An epitope is the portion of an antigen that is recognized by cells of the immune system
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How do IgM, IgA and IgG differ in avidity?
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IgG has two identical variable regions
So does IgA, but IgA can form a dimer which gives it four identical variable regions IgM forms a pentamer - with a total of ten identical variable regions |
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What region on the immunoglobulin determines its effector function?
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Fc - constant region
Class switching (AID) from IgM (and IgD) to other classes - IgA, IgG, IGE |
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Describe the structure of the TCR
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β chain (=heavy), α chain (=light)
variable vs constant regions |
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What type of antigen is recognized by the TCR
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A composite of a linear peptide and MHC molecule
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What form of epitope do TCRs recognize?
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linear
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CD4 co-receptors recognize which molecule?
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MHC II
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CD8 co-receptors recognize which molecule?
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MHC I
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Which cells express MHC I?
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All nucleated cells
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Which cells express MHC II?
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Antigen Presenting Cells (APCs)
(Macrophages, Dendritic Cells, B cells) |
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What allows for presentation of different peptide repertoires?
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Polymorphisms in MHC
??Population or individual?? |
