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30 Cards in this Set
- Front
- Back
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Describe the pathway which produces proteins and loads them onto MHC I
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a
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Describe the pathway which produces proteins and loads them onto MHC II
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a
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How do interferons regulate antigen processing and presentation?
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a
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*What is the difference between the terms polymorphic and polygenic as they relate to MHC?
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a
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The existence of what factor contributes to an improved immune response?
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Diversity in MHC
(increases the diversity of peptides recognized) (codominant expression increases as well ?heterogenity?) |
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Name (7) proteins important to antigen processing and presentation
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Proteasome, TAP, Cathepsin S and cathepsin L, invariant chain, CLIP peptide, HLA-DM
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What does Proteasome do?
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a
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What does TAP do?
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a
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What does Cathepsin S do?
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a
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What does Cathepsin L do?
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a
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What does the invariant chain do?
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a
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What does the CLIP peptide do?
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a
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What does HLA-DM do?
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a
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*The phosphorylation of this receptor is important for TCR, BCR and Fc receptor sgnaling
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ITAM (Immunoreceptor tyrosine-based activation motif)
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What enhances receptor signaling?
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Co-stimulatory receptors
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Signal 2 is given by what molecules?
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Co-stimulatory receptors
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Name three proteins involved in TCR signaling
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CD3, Lck, CD28
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What does CD3 do?
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a
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What does Lck do?
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a
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What does CD28 do?
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a
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Name six proteins associated with BCR signaling
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Iga, IgB, Btk, CD19/CD21/CD18
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What proteins form a complex involved in BCR signaling
What is this complex analogous to in TCR signaling? |
CD19/CD21/CD18
a |
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What does Iga:IgB do?
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a
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What does Btk do?
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a
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What does CD19 do?
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a
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What does CD21 do?
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a
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What does CD18 do?
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a
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What is the end product of signaling in T cells?
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IL-2
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What is the role of IL-2?
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Survival, proliferation, growth
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How do cyclosporine and FK5-6 act as immunosuppressants?
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a
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