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6 Cards in this Set
- Front
- Back
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Allelic Exclusion
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In reference to antibody production, the case that in a heterozygous individual, only one of the 2 c-region alleles at the Ig - heavy chain or light chain loci is expressed in each B cell.
In the B cell population for each locus roughly half of the cells express one allele and the remaining cells express the other. |
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Isotype Switch
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The process by which a B cell changes the class of Ig it makes while preserving the antigenic specificity.
Isotype switching involves a somatic recombination process that attaches a different heavy chain constant region gene to the existing variable region exon. |
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Somatic Hypermutation
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Mutation that occurs at High frequency in the rearranged variable region DNA of Ig genes in activated B cells, resulting in the production of variant antibodies.
Some of which have a higher affinity for the antigen. |
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Surrogate Light Chain
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Protein that mimics the light chain.
Forms a complex with the m (mu) chain to form pre-BCR |
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Antigenic Determinant
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A part of the antigen that is bound by the BCR or Ab or gives rise to MHC binding peptide recognised by TCR
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Co-Stimulatory molecule
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A molecule on an APC that delivers activation signals to the interacting T-Cell.
e.g. CD80 = B7-1; CD86=B7-2 |
