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8 Cards in this Set
- Front
- Back
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What are two types of primary immunodeficiencies of the innate immune system?
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Phagocytic cell defects and Complement system defects
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What are three types of primary immunodeficiencies in the adaptive immune system?
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Primary B cell deficiencies, Primary T cell deficiencies, Primary T cell dysfunction
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What are the causees of secondary immunodeficiency?
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depletion of lymphocytes, destruction of lymphocytes by irradiation, destruction of lympocytes by chemical modulation (hormones, alkylating agents, metabolic inhibitors, antibiotics), viruses
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Name three types of phagocytic cell defects in primary immunodeficiency?
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chronic granulomatous disease, chediak-hiashi disease, leukocyte adhesion deficiency
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What is a granuloma?
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aggregation of macrophages attempting to kill an antigen
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What are examples of primary B cell deficiencies?
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IgA deficiency, Burton's X-linked agammaglobulinemia (XLA), Common variable immunodeficiency, X-linked IgM syndrome
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What are examples of primary T cell deficiences?
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Digeorges and Nezelof syndromes (failure of thymus development, no T cells, susceptible to viral infection)
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What are examples of primary T cell dysfunction?
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SCID, Bare lymphocyte syndrome, reticular dysgenesis, Wiskott-alderish syndrome, ataxia telangiectasia, recognition of defects
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