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42 Cards in this Set
- Front
- Back
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are hives a result of edema (histamine) or an inflammatory response?
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edema
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difference between allergy and hypersensitivity?
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allergy not pathogenic
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inf-gamma induces what kind of cells (in addition to killer cells)?
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th2 via stimulation of il-4 and il-13
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how does igE attach to mast cells?
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via high affinity receptor fc-epsilon-1
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which type of hypersen. is immediate?
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type I
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which antibody is involved with type I?
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igE
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what conditions are type I?
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seasonal, asthma (50%), anaphylaxis, atopic dermatitis
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can igE isotype switch/?
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No
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54% of asthmatics have what disease?
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atopic
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does igE fix complement?
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no
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igE is not seen in what allergens?
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food
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igE responses are how many phases? what are they? how long?
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1. biphasic
2. mast cell mediated, then eosinophil mediated 3. 30 minutes, 6-12 hours |
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most common atopic disease?
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allergic rhinitis
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what drugs treat allergic rhinitis?
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avoidance, antihistamines, cromolyn sodium, steroids, desensitization
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which kinds of hypersen. can pcn cause?
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i, ii, iii
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which ig is type ii?
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igg
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what is type ii called?
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cytotoxic
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what are the big 2 in type ii?
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adcc and complement mediated cell lysis
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what are the autoimmune rxns in type ii?
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goodpasture's, pemphigus, myasthenia gravis, type I dm
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goodpasture's localizes where?
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kidney and lung
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pemphigus is anti what?
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anti-desmoglein 3
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what is myasthenia gravis?
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autoantibodies block ach receptor
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how does type i dm occur?
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anti-islet antibodies
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what does direct coomb's check?
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if you have antibodies on cell surface
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which type has antigens as soluble in blood or lymph?
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iii
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how do petechia get formed? which type hyper?
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ab-ag complexes form in caps; open endothelial cells; type iii
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2 types of type iii rxns?
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1. contained in bv is serum sickness
2. out of bv is arthus rxn |
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what type iii rxn shoes pinpoint bruising?
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serum sickness
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which type iii rxn is very long first exposure?
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arthus rxn
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what conditions cause type iii?
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1. chronic infections
2. autoimmunity 3. inhaled antigen hypersen. |
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skin appearance in type iii vs type ii rxn?
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iii-punctuate and granular; ii is smooth
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tx of type ii?
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steroids, ig, immunosupp.
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type iii tx?
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steroids, immunosupp.,antibiotics
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type iv also called?
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delayed/cellular
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what conditions are type iv?
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contact derm, ppd rxn., granulomas
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is type iv th1 or th2?
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th1
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type i diagnosed w/ what test?
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skin: wheel and flare
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what causes the wheel? the flare?
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wheel-histamine; flare-inflammation
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mast cell areas?
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mucosal and connective tissue; mucosal is more connective has more histamine
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basophils aka
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mobile mast cells
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what is in a mast cell?
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histamine, tryptase, chymase, carboxypeptidase
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mast cells produce what upon stimulation?
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leukotrienes, prostaglandins, paf, cytokines, chemotactic factors
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