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35 Cards in this Set
- Front
- Back
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CCR9
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acquired by T lymphocytes following activation in Peyer's Patch
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alpha4:beta7
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binds to MAdCAM-1 to allow lymphocytes reentry into lamina propria
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CCR7
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retained by central memory T cells that remain in lymphoid tissues
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gp120
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HIV molecule that binds CCR5, CXCR4 & CD4
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gp41
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HIV molecule that fuses with T-cell membrane after gp120 binding
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CD45RA
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expressed by naive T lymphocytes
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CD45RO
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expressed by effector/memory T lymphocytes
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DC-sign
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used by intraepithelial DC's to bind HIV
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CD40L
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ligand that T cells use to bind B cells for isotype switching and activate macrophage (Hyper IgM)
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CD18
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LFA subunit used to facilitate tight binding of neutrophils (leukocyte adhesion deficiency)
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Rh
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protein marker on erythrocytes (hemolytic disease of the newborn)
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MIC-A,B
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expressed by stressed gastrointestinal epithelial cells; binds NKG2D on odd-type IEL's to induce apoptosis
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Odd (type b) CD8
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IEl that express alpha:alpha CD8, either alpha:beta or gamma:delta TCR, & NKG2D
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Promote IgE
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IL-4
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Inhibit IgE
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IFN-y
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Promote IgA
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TGF-beta
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Augment IgA
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IL-5
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L. major
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Th1
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T gondii
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Th1
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M. leprae
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Th1 (Th2 antibody response ineffective)
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intestinal helminths
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Th2 (Th1 response is damaging)
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inhibit Th17
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IL-4, IFNY-y
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Inhibit Th1
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IL-4 & IL-10; TGF-b
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Inhibit Th2
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IFN-y; TGF-b
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Neutrophil recruitment
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IL-6, IL-17
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activate macrophage; increase MHC II expression
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IFN-y
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Promote B cell prolif
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IL-4
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Promote Treg
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DC: high TGF-b, low IL-6, 23
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Promote Th17
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DC: high TGF-b, IL-6, 23
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Promote Th1
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DC: IL-12; NK: IFN-y
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Promote Th2
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NK T cell: IL-4
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Treg secrete
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TGF-b
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Th17 secrete
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IL-6, 17 (neutrophil recruitment)
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Th1 secrete
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IL-2, IFN-y, LT
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Th2 secrete
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IL-4, IL-5, IL-10
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