Immunology Exam 1

Front 1

neutrophils

Back 1

PMN leukocytes
major class of WBC in peripheral blood
multilobed nuclei and neutrophilic granules.
phagocytes with an important role in entering infected tissues and engulfing and killing extracellular pathogens.

Front 2

plasma cells

Back 2

terminally differentiated b lymphos
main Ab-secreting cells
found in the medulla of lymph nodes and in BM

Front 3

mast cells

Back 3

large cells in connective tissue
most abundant in submucosal tissues
contain large granules that store mediator molecules including histamine.

Front 4

mature b cell

Back 4

surface Ig: IgD and IgM made from alternatively spliced H chain
regulated by RNA processing

Front 5

clonal selection theory

Back 5

adaptive immunity
adaptive immune responses derive from individual Ag-specific lymphocytes that are self tolerant.
these proliferate in response to Ag and differentiate into Ag-specific effector cells, then into memory cells

Front 6

pre-B cells

Back 6

H chain: v-d-j rearranged
L chain: v-j rearranged
surface Ig: mu on chain surface.

Front 7

pro-B cells

Back 7

H chain: D-J rearranged, then V-D-J
L chain: germline
surface Ig: absent

Front 8

IgE

Back 8

e heavy chains
involved in defense against parasitic infections and allergic reactions

Front 9

IgD

Back 9

delta heavy chains
appears as surface Ig
function unknown

Front 10

IgA

Back 10

alpha heavy chains
main Ab class secreted by mucosal lymphoid tissues

Front 11

B-1 cells

Back 11

CD 5 B cells
class of atypical self-renewing
found mainly in peritoneal and pleural cavities

Front 12

productive v. nonproductive rearrangements

Back 12

each rearrangement has a 1/3 chance of being in the correct reading frame.
each b cell has 2 copies of H chain and a k and L light chain

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epitope

Back 13

site on Ag recognized by Ab or an Ag receptor. also caleld Ag determinants.
b cell: structural motifs

Front 14

IgM

Back 14

mu heavy chains
1st to appear on B cell surface and 1st to be secreted

Front 15

B stem cell

Back 15

H chain/L chain: germline
surface Ig: absent

Front 16

immature B cell

Back 16

H chain: VDJ rearranged
L chain: VJ rearranged
Surface Ig: IgM expressed on cell surface

Front 17

CDR

Back 17

complementarity determining regions
hypervariable domains
3 in each v region
*engage the epitope

Front 18

somatic hypermutation

Back 18

V region sequence undergoes during B cell responses
Increase Ab affinity and are not inherited
occurs after B cells leave the BM.

Front 19

RAG 1&2

Back 19

recombinase activating genes
recognize SS and align
lymphocyte specfic
involved in somatic recombination

Front 20

lymphocytes

Back 20

WBC with variable cell surface receptors
involved in humoral and cell-mediated immunity.